7e20
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state== |
| - | <StructureSection load='7e20' size='340' side='right'caption='[[7e20]]' scene=''> | + | <StructureSection load='7e20' size='340' side='right'caption='[[7e20]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e20]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E20 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e20 OCA], [https://pdbe.org/7e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e20 RCSB], [https://www.ebi.ac.uk/pdbsum/7e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e20 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e20 OCA], [https://pdbe.org/7e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e20 RCSB], [https://www.ebi.ac.uk/pdbsum/7e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e20 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/AT1B1_HUMAN AT1B1_HUMAN]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).<ref>PMID:19694409</ref> <ref>PMID:34011520</ref> Involved in cell adhesion and establishing epithelial cell polarity.<ref>PMID:19694409</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Chi XM]] |
| + | [[Category: Guo YY]] | ||
| + | [[Category: Huang BD]] | ||
| + | [[Category: Wu LS]] | ||
| + | [[Category: Yan RH]] | ||
| + | [[Category: Ye FF]] | ||
| + | [[Category: Zhang YY]] | ||
| + | [[Category: Zhou Q]] | ||
Revision as of 05:21, 8 September 2022
Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state
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Categories: Homo sapiens | Large Structures | Chi XM | Guo YY | Huang BD | Wu LS | Yan RH | Ye FF | Zhang YY | Zhou Q
