1hbx

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[[Image:1hbx.gif|left|200px]]
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{{STRUCTURE_1hbx| PDB=1hbx | SCENE= }}
{{STRUCTURE_1hbx| PDB=1hbx | SCENE= }}
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'''TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA'''
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===TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA===
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==Overview==
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The serum response element (SRE) is found in several immediate-early gene promoters. This DNA sequence is necessary and sufficient for rapid transcriptional induction of the human c-fos proto-oncogene in response to stimuli external to the cell. Full activation of the SRE requires the cooperative binding of a ternary complex factor (TCF) and serum response factor (SRF) to their specific DNA sites. The X-ray structure of the human SAP-1-SRF-SRE DNA ternary complex was determined (Protein Data Bank code 1hbx). It shows SAP-1 TCF bound to SRF through interactions between the SAP-1 B-box and SRF MADS domain in addition to contacts between their respective DNA-binding motifs. The SAP-1 B-box is part of a flexible linker of which 21 amino acids become ordered upon ternary complex formation. Comparison with a similar region from the yeast MATalpha2-MCM1-DNA complex suggests a common binding motif through which MADS-box proteins may interact with additional factors such as Fli-1.
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The line below this paragraph, {{ABSTRACT_PUBMED_11406578}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11406578 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11406578}}
==About this Structure==
==About this Structure==
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[[Category: Ternary complex factor]]
[[Category: Ternary complex factor]]
[[Category: Transcription complex]]
[[Category: Transcription complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:40:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:57:39 2008''

Revision as of 04:57, 1 July 2008

Image:1hbx.png

Template:STRUCTURE 1hbx

TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA

Template:ABSTRACT PUBMED 11406578

About this Structure

1HBX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex., Hassler M, Richmond TJ, EMBO J. 2001 Jun 15;20(12):3018-28. PMID:11406578

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