3f5m

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Current revision (15:26, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hig|2hig]], [[1pfk|1pfk]], [[2pfk|2pfk]], [[3pfk|3pfk]], [[4pfk|4pfk]], [[1mto|1mto]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [https://pdbe.org/3f5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [https://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [https://pdbe.org/3f5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [https://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
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[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-phosphofructokinase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fothergill-Gilmore, L A]]
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[[Category: Trypanosoma brucei]]
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[[Category: Keillor, J W]]
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[[Category: Fothergill-Gilmore LA]]
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[[Category: Martinez-Oyanedel, J]]
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[[Category: Keillor JW]]
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[[Category: McNae, I W]]
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[[Category: Martinez-Oyanedel J]]
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[[Category: Michels, P A.M]]
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[[Category: McNae IW]]
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[[Category: Walkinshaw, M D]]
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[[Category: Michels PAM]]
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[[Category: 6-phospho-1-fructokinase]]
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[[Category: Walkinshaw MD]]
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[[Category: Atp binding]]
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[[Category: Atp-binding]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Kinase activity]]
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[[Category: Nucleotide-binding]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei

PDB ID 3f5m

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