3qy7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:50, 21 February 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3qy7' size='340' side='right'caption='[[3qy7]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='3qy7' size='340' side='right'caption='[[3qy7]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qy6|3qy6]], [[3qy8|3qy8]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [https://pdbe.org/3qy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [https://pdbe.org/3qy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU]] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>
+
[https://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Unique metal-dependent protein tyrosine phosphatases that belong to the polymerase and histindinol phosphatase (PHP) family are present in Gram-positive bacteria. They are distinct from the Cys-based, low-molecular-weight phosphotyrosine protein phosphatases (LMPTPs). Two representative members of the PHP family tyrosine phosphatases are YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae. YwqE is involved in polysaccharide biosynthesis, bacterial DNA metabolism, and DNA damage response in B. subtilis. CpsB regulates capsular polysaccharide biosynthesis via tyrosine dephosphorylation of CpsD, its cognate tyrosine kinase, in S. pneumoniae. To gain insights into the active site and possible conformational changes of the metal-dependent tyrosine phosphatases from Gram-positive bacteria, we have determined the crystal structures of B. subtilis YwqE (in both the apo form and the phosphate-bound form) and S. pneumoniae CpsB (in the sulfate-bound form). Comparisons of the three structures reveal conformational plasticity of two active site loops. Furthermore, in both structures of the phosphate-bound YwqE and the sulfate-bound CpsB, the phosphate (or sulfate) ion is bound to a cluster of three metal ions in the active site, thus providing insight into the pre-catalytic state.
+
-
 
+
-
Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases.,Kim HS, Lee SJ, Yoon HJ, An DR, Kim DJ, Kim SJ, Suh SW J Struct Biol. 2011 May 14. PMID:21605684<ref>PMID:21605684</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3qy7" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
Line 28: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Vibrio subtilis ehrenberg 1835]]
+
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: An DR]]
-
[[Category: An, D R]]
+
[[Category: Kim DJ]]
-
[[Category: Kim, D J]]
+
[[Category: Kim HS]]
-
[[Category: Kim, H S]]
+
[[Category: Kim S-J]]
-
[[Category: Kim, S J]]
+
[[Category: Lee SJ]]
-
[[Category: Lee, S J]]
+
[[Category: Suh SW]]
-
[[Category: Suh, S W]]
+
[[Category: Yoon HJ]]
-
[[Category: Yoon, H J]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Phosphatase]]
+
-
[[Category: Tim barrel]]
+

Current revision

Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases

PDB ID 3qy7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qy7"
Personal tools