3rbg

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Revision as of 12:17, 14 March 2024

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

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Retrieved from "http://52.214.119.220/wiki/index.php/3rbg"

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 <StructureSection load='3rbg' size='340' side='right'caption='[[3rbg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3rbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3rbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRTAM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbg OCA], [https://pdbe.org/3rbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbg RCSB], [https://www.ebi.ac.uk/pdbsum/3rbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7]
+[https://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7]
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The members of the immunoglobulin superfamily (IgSF) control innate and adaptive immunity and are prime targets for the treatment of autoimmune diseases, infectious diseases, and malignancies. We describe a computational method, termed the Brotherhood algorithm, which utilizes intermediate sequence information to classify proteins into functionally related families. This approach identifies functional relationships within the IgSF and predicts additional receptor-ligand interactions. As a specific example, we examine the nectin/nectin-like family of cell adhesion and signaling proteins and propose receptor-ligand interactions within this family. Guided by the Brotherhood approach, we present the high-resolution structural characterization of a homophilic interaction involving the class-I MHC-restricted T-cell-associated molecule, which we now classify as a nectin-like family member. The Brotherhood algorithm is likely to have a significant impact on structural immunology by identifying those proteins and complexes for which structural characterization will be particularly informative.
-Functional classification of immune regulatory proteins.,Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034<ref>PMID:23583034</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3rbg" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Almo, S C]]
+[[Category: Almo SC]]
-[[Category: Fiser, A]]
+[[Category: Fiser A]]
-[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
+[[Category: Nathenson SG]]
-[[Category: Structural genomic]]
+[[Category: Ramagopal UA]]
-[[Category: Nathenson, S G]]
+[[Category: Rubinstein R]]
-[[Category: Ramagopal, U A]]
+[[Category: Toro R]]
-[[Category: Rubinstein, R]]
-[[Category: Toro, R]]
-[[Category: Atoms-to-animals: the immune function network]]
-[[Category: Crtam]]
-[[Category: Ifn]]
-[[Category: Igv]]
-[[Category: Immune system]]
-[[Category: Nysgrc]]
-[[Category: Psi-biology]]

3rbg

From Proteopedia

Revision as of 12:17, 14 March 2024

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

Structural highlights

Function

References

Contents

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