3rbw

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<StructureSection load='3rbw' size='340' side='right'caption='[[3rbw]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3rbw' size='340' side='right'caption='[[3rbw]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rbw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rbw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3r7g|3r7g]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPIRE1, KIAA1135, SPIR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbw OCA], [https://pdbe.org/3rbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbw RCSB], [https://www.ebi.ac.uk/pdbsum/3rbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbw OCA], [https://pdbe.org/3rbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbw RCSB], [https://www.ebi.ac.uk/pdbsum/3rbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPIR1_HUMAN SPIR1_HUMAN]] Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.<ref>PMID:11747823</ref> <ref>PMID:21620703</ref>
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[https://www.uniprot.org/uniprot/SPIR1_HUMAN SPIR1_HUMAN] Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.<ref>PMID:11747823</ref> <ref>PMID:21620703</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Eck, M J]]
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[[Category: Eck MJ]]
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[[Category: Kreutz, B]]
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[[Category: Kreutz B]]
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[[Category: Lu, J]]
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[[Category: Lu J]]
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[[Category: Quinlan, M E]]
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[[Category: Quinlan ME]]
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[[Category: Rodal, A A]]
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[[Category: Rodal AA]]
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[[Category: Toms, A V]]
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[[Category: Toms AV]]
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[[Category: Vizcarra, C L]]
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[[Category: Vizcarra CL]]
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[[Category: Zheng, W]]
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[[Category: Zheng W]]
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[[Category: Actin nucleator]]
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[[Category: C-lobe of protein kinase]]
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[[Category: Fmn-family formin]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of Spire KIND domain

PDB ID 3rbw

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