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Tyrosine phosphatase 3D structures

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*'''Class I'''
*'''Class I'''
-
*'''Non-receptor type tyrosine phosphatase'''
+
*'''Non-receptor type tyrosine phosphatase; Domains – catalytic 1-321;'''
-
**[[5k9v]] – hPTPN1 - human<br />
+
**[[8u1e]] - hPTP-1b catalytic domain - human<br />
-
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br />
+
**[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j, [[6ntp]], [[6xe8]], [[6xee]], [[7key]], [[7l0c]], [[7lfo]], [[7rin]] - hPTP-1b catalytic domain <br />
-
**[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]], [[6b8e]], [[6b8t]], [[6b8x]], [[6b90]], [[6ntp]], [[6ol4]], [[6olq]], [[6olv]], [[6omy]], [[6pfw]], [[6pg0]], [[6pha]], [[6pgt]], [[6phs]], [[6pm8]], [[6xe8]], [[6xee]], [[7key]], [[7l0c]], [[7lfo]], [[7rin]] - hPTP1B catalytic domain 1-321<br />
+
**[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[6olq]], [[6olv]], [[6omy]], [[6pfw]], [[6pg0]], [[6pgt]], [[6pha]], [[6phs]], [[6cwv]], [[6cwu]], [[7fre]], [[7frs]], [[7frt]], [[7fru]], [[7gsc]], [[7gtw]], [[7gtx]], [[7gty]], [[7gtz]], [[7gu0]], [[7gu1]], [[7gu2]], [[7gu3]], [[7gu4]], [[7gu5]], [[7gu6]], [[7gu7]], [[7gu8]], [[7gu9]], [[7gua]], [[7gub]], [[7guc]], [[7ken]], [[7mkz]], [[7mn9]], [[7mnc]], [[7mou]], [[7mov]], [[7s4f]], [[8du7]], [[8exi]], [[8xoy]] - hPTP-1b catalytic domain (mutant)
-
**[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]], [[6bai]], [[6olq]], [[6olv]], [[6omy]], [[6pfw]], [[6pg0]], [[6pgt]], [[6pha]], [[6phs]], [[6cwv]], [[6cwu]], [[7ken]], [[7mnc]] - hPTP1B catalytic domain (mutant) <br />
+
**[[3lnx]] - hPTP-1e PDZ2 domain 1361-1456<br />
-
**[[3pdz]] - hPTP-1E PDZ2 domain – NMR<br />
+
**[[3pdz]], [[7qcx]] - hPTP-1e PDZ2 domain – NMR<br />
 +
**[[2m0z]] - hPTP-1e PDZ2 domain (mutant) – NMR<br />
 +
**[[5k9v]] – hPTPN1 catalytic domain<br />
 +
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 catalytic domain (mutant)<br />
**[[6zz4]], [[7f5n]], [[7f5o]] – hPTPN2 catalytic domain <br />
**[[6zz4]], [[7f5n]], [[7f5o]] – hPTPN2 catalytic domain <br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
-
**[[2i75]] – hPTPN4<br />
+
**[[2i75]] – hPTPN4 611-926<br />
-
**[[2cs5]] – hPTPN4 PDZ domain – NMR<BR />
+
**[[2cs5]] – hPTPN4 PDZ domain 507-612 – NMR<br />
**[[2vph]] - hPTPN4 PDZ domain<br />
**[[2vph]] - hPTPN4 PDZ domain<br />
-
**[[2bij]] – hPTPN5 catalytic domain<br />
+
**[[2bij]], [[8sls]], [[8slt]], [[8slu]] – hPTPN5 catalytic domain 258-561<br />
**[[2bv5]] - hPTPN5 catalytic domain (mutant) <br />
**[[2bv5]] - hPTPN5 catalytic domain (mutant) <br />
-
**[[4hjp]], [[1gwz]], [[2b3o]] – hPTPN6 catalytic domain <br />
+
**[[1zco]], [[2a3k]] – hPTPN7 65-358<br />
-
**[[4gry]], [[4grz]], [[4hjq]], [[3ps5]] – hPTPN6 catalytic domain (mutant)<br />
+
**[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm,]] [[2qdp]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 65-360 (mutant) <br />
-
**[[2dn7]] - hPTPN6 FN3 #6 domain - NMR<br />
+
**[[2pa5]] – hPTPN9 catalytic domain 277-582<br />
-
**[[2dju]], [[2edy]] - hPTPN6 FN3 domain - NMR<br />
+
**[[5hde]] - hPTPN12 catalytic domain 1-301<br />
-
**[[1x6c]] - hPTP hPTPN6 SH2 domain – NMR<BR />
+
**[[5glj]] - hPTPN13 PDZ1 domain 1086-1178<br />
-
**[[2a3k]], [[1zc0]] – hPTPN7 catalytic domain<br />
+
**[[1wch]] - hPTPN13 2163-2477<br />
-
**[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[2qds]], [[2qdt]], [[2qdu]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 catalytic domain (mutant) <br />
+
**[[2bzl]] – hPTPN14 catalytic domain 886-1187<br />
-
**[[2pa5]] – hPTPN9 catalytic domain<br />
+
**[[2oc3]] – hPTPN18 catalytic domain 6-299<br />
-
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
+
**[[8gvl]] – hPTPN21 FERM domain 18-318<br />
-
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[7emn]] - hPTPN11 catalytic domain (mutant)<br />
+
**[[8gvv]] – hPTPN21 PTP domain 876-1174 (mutant)<br />
-
**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
+
**[[8gxe]] – hPTPN21 FERM+PTP domains <br />
-
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]] - hPTPN11 SH2+catalytic domains (mutant)<br />
+
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain 1-302<br />
-
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[6atd]], [[2shp]] - hPTPN11 catalytic domain (mutant)<br />
+
-
**[[5hde]] - hPTPN12 catalytic domain <br />
+
-
**[[5glj]] - hPTPN13 PDZ1 domain <br />
+
-
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
+
-
**[[6gdb]] - hPTPN13 PDZ3 domain - NMR<br />
+
-
**[[3pdz]] - hPTPN13 PDZ2 domain – NMR<BR />
+
-
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
+
-
**[[2bzl]] – hPTPN14 catalytic domain<br />
+
-
**[[2oc3]] – hPTPN18<br />
+
-
**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
+
**[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br />
**[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br />
**[[5lm2]] – hRPTP23 residues 362-713<br />
**[[5lm2]] – hRPTP23 residues 362-713<br />
-
**[[1xm2]], [[1rxd]] – hPTP PRL-1<br />
+
**[[1rxd]], [[1xm2]] – hPTP PRL-1<br />
-
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR />
+
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<br />
-
**[[1rxd]] - hPTP IVA-1<br />
+
**[[1bvh]] - bPTP – bovine – NMR <br />
-
**[[1gwz]], [[2b3o]] – hPTP SHP-1 catalytic domain<br />
+
-
**[[1x6c]] - hPTP SHP-1 SH2 domain 105-220 – NMR<br />
+
-
**[[6cmq]] - hPTP SHP-2 106-529<br />
+
-
**[[7emn]], [[6crf]], [[6cmp]] - hPTP SHP-2 (mutant)<br />
+
**[[1c0e]] – bPTP (mutant) – bovine<br />
**[[1c0e]] – bPTP (mutant) – bovine<br />
-
**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR />
+
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
-
**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR />
+
**[[3i36]] – rPTP- catalytic domain<br />
 +
**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<br />
 +
**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<br />
**[[3rgo]] – mPTP-1<br />
**[[3rgo]] – mPTP-1<br />
 +
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br />
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br />
-
**[[6x39]] – mPTP F FN5 domain <br />
+
**[[6x39]] – mPTP F FN#5 domain <br />
-
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
+
**[[6gbd]] – mPTP-13 SH3 domain - NMR<br />
-
**[[3i36]] – rPTP-η catalytic domain<br />
+
**[[2pi7]] – cPTP CRYP-2 catalytic domain – chicken<br />
-
**[[2pi7]] – cPTP CRYP-2 catalytic domain - chicken<br />
+
**[[7mod]], [[7moi]], [[7moj]], [[7mok]], [[7mol]], [[7mom]] – AtPTP DSP1 49-215 – Arabidopsis thaliana <br />
-
**[[7mod]], [[7moi]], [[7moj]], [[7mok]], [[7mol]], [[7mom]] – AtPTP DSP1 – ''Arabidopsis thaliana'' <br />
+
**[[6krw]], [[6krx]] – AtPTP1 1-340 <br />
-
**[[1d1p]], [[2j16]], [[6byf]] – yPTP - yeast<br />
+
**[[1d1p]], [[2j16]] – yPTP – yeast<br />
**[[2j17]] - yPTP (mutant)<br />
**[[2j17]] - yPTP (mutant)<br />
**[[5xw4]] – yPTPN CDC14 <br />
**[[5xw4]] – yPTPN CDC14 <br />
-
**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br />
+
**[[6e3b]] – yPTPN SIW14 catalytic domain <br />
-
**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br />
+
**[[1g4w]] – StPTP – Salmonella typhimurium<br />
-
**[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – ''Shewanella''<br />
+
**[[2i6i]], [[3ro1]] – SsPTP – Sulfolobus solfataricus<br />
-
**[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br />
+
**[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – Shewanella<br />
-
**[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br />
+
**[[3js5]], [[3jvi]] – EhPTP – Entamoeba histolytica<br />
-
**[[5z59]], [[5z5a]] – TkPTP – ''Thermococcus kodakarensis'' <br />
+
**[[2wjd]], [[2wje]], [[2wjf]] – PTP – Streptococcus pneumonia<br />
-
**[[5z5b]] - TkPTP (mutant)<br />
+
**[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – Bacillus subtilis <br />
-
**[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis'' <br />
+
**[[4d74]] – PTP AMSI 1-144 (mutant) – Erwinia amylovora <br />
 +
**[[8dhi]], [[8dhj]] – PTP 1-246 (mutant) – Clostridioides difficile <br />
*Non-receptor type PTP complex with peptide
*Non-receptor type PTP complex with peptide
-
**[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br />
+
**[[1ptt]], [[1ptu]], [[1g1f,]] [[1g1g]], [[1g1h]], [[1een]], [[1eeo]], [[8exj]], [[8exk]], [[8exm]], [[8exn]], [[8eya]], [[8eyb]], [[8eyc]], [[8f88]] - hPTP-1b catalytic domain (mutant) + peptide<br />
-
**[[3i7z]] - hPTP1B catalytic domain + peptide<br />
+
**[[3i7z]] - hPTP-b catalytic domain + peptide<br />
-
**[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP1B catalytic domain (mutant) + peptide<br />
+
**[[7qcy]] - hPTP-1e PDZ2 domain + peptide – NMR<br />
-
**[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br />
+
[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br />
-
**[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br />
+
-
**[[6hks]] – hPTPN3 489-597 + peptide<br />
+
**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) 628-909 + peptide<br />
**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) 628-909 + peptide<br />
 +
**[[6hks]], [[6t36]], [[8cqy]], [[8oep]] – hPTPN3 PDZ domain 489-597 + peptide<br />
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
**[[7vze]] - hPTPN4 PDZ domain + papillomavirus peptide<br />
**[[7vze]] - hPTPN4 PDZ domain + papillomavirus peptide<br />
-
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
 
-
**[[4gs0]], [[1fpr]] – hPTPN6 catalytic domain + peptide<br />
 
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
-
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
+
**[[4icz, [[6kzq]], [[6l03]] – hPTPN9 catalytic domain + peptide<br />
-
**[[3tl0]], [[3tkz]],[[5df6]], [[4qsy]],[[5x94]], [[5x7b]] – hPTPN11 SH2 domain + peptide<br />
+
**[[5o2p]] – hPTPN12 SH3 domain/peptide<br />
**[[5o2p]] – hPTPN12 SH3 domain/peptide<br />
-
**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
+
**[[3lny]], [[7xty]] - hPTPN13 PDZ2 domain 1362-1456 + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
**[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br />
**[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
-
**[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + STAM2 peptide<br />
+
**[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + peptide<br />
**[[5lm1]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
**[[5lm1]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
-
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
 
-
**[[6roy]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide <br />
 
-
**[[6roz]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITSM peptide <br />
 
-
**[[6r5g]] - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR<br />
 
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
-
**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br />
+
**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide <br />
**[[1vj6]] – mPTP-BL PDZ2 domain + APC C terminal – NMR<br />
**[[1vj6]] – mPTP-BL PDZ2 domain + APC C terminal – NMR<br />
**[[6gbe]] – mPTPN13 PDZ3 domain + PRK2 peptide – NMR<br />
**[[6gbe]] – mPTPN13 PDZ3 domain + PRK2 peptide – NMR<br />
Line 109: Line 94:
**[[6g86]] – yPTPN CDC14 + SIC1 peptide<br />
**[[6g86]] – yPTPN CDC14 + SIC1 peptide<br />
**[[6g85]], [[6g84]] – yPTPN CDC14 + CBK1 peptide<br />
**[[6g85]], [[6g84]] – yPTPN CDC14 + CBK1 peptide<br />
-
**[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br />
+
**[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide <br />
*Non-receptor type PTP complex with small molecule
*Non-receptor type PTP complex with small molecule
-
**[[1ptv]], [[1pty]] - hPTP1B catalytic domain (mutant) + phosphotyrosine<br />
+
**[[1ptv]], [[1pty]] - hPTP-1b catalytic domain (mutant) + phosphotyrosine<br />
-
**[[1aax]] - hPTP1B catalytic domain (mutant) + bis-phosphophenyl methane<br />
+
**[[1aax]] - hPTP-1b catalytic domain (mutant) + bis-phosphophenyl methane<br />
-
**[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[6bmr]], [[6bmv]], [[6bmx]], [[6bmu]], [[6bmw]], [[6bmy]], [[5t19]], [[5k9w]], [[6b8z]], [[5t19]], [[5k9w]], [[6w30]], [[7klx]], [[7mm1]] - hPTP1B catalytic domain + inhibitor<br />
+
**[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk,]] [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng,]] [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[5t19]], [[5k9w]], [[6w30]], [[7gs7]], [[7gsa]], [[7gsb]], [[7gsl]], [[7gsm]], [[7gso]], [[7gsr]], [[7gst]], [[7gsv]], [[7gsw]], [[7gsy]], [[7gt0]], [[[7gt1]], [7gt3]], [[7gt4]], [[7gt5]], [[7gt6]], [[7gt7]], [[7gt9]], [[7gta]], [[7gtd]], [[7gte]], [[7gtg]], [[7gth]], [[7gti]], [[7gtk]], [[7gtl]], [[7gtm]], [[7gtn]], [[7gto]], [[7gtt]], [[7gtu]], [[7klx]], [[7mm1]], [[8g6a]], [[8g65]], [[8g67]], [[8g68]], [[8g69]], [[8skl]] - hPTP-1b catalytic domain 1-298 + inhibitor<br />
-
**[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[6b95]], [[1nwl]], [[1nwe]], [[2fjm]], [[6bn5]], [[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[5qgf]], [[5qge]], [[5qgd]], [[5qgc]], [[5qgb]], [[5qga]], [[5qg9]], [[5qg8]], [[5qg7]], [[5qg6]], [[5qg5]], [[5qg4]], [[5qg3]], [[5qg2]], [[5qg1]], [[5qg0]], [[5qfz]], [[5qfx]], [[5qfw]], [[5qfv]], [[5qfu]], [[5qft]], [[5qfs]], [[5qfr]], [[5qfq]], [[5qfp]], [[5qfo]], [[5qfn]], [[5qfm]], [[5qfl]], [[5qfk]], [[5qfj]], [[5qfi]], [[5qfh]], [[5qfg]], [[5qff]], [[5qfe]], [[5qfd]], [[5qfc]], [[5qfb]], [[5qfa]], [[5qf9]], [[5qf8]], [[5qf7]], [[5qf6]], [[5qf5]], [[5qf4]], [[5qf3]], [[5qf2]], [[5qf1]], [[5qf0]], [[5qez]], [[5qex]], [[5qew]], [[5qev]], [[5qeu]], [[5qet]], [[5qes]], [[5qer]], [[5qeq]], [[5qep]], [[5qeo]], [[5qen]], [[5qem]], [[5qel]], [[5qek]], [[5qej]], [[5qei]], [[5qeh]], [[5qeg]], [[5qef]], [[5qee]], [[5qed]], [[5qec]], [[5qeb]], [[5qea]], [[5qe9]], [[5qe8]], [[5qe7]], [[5qe6]], [[5qe5]], [[5qe4]], [[5qe3]], [[5qe2]], [[5qe1]], [[5qe0]], [[5qdz]], [[5qdx]], [[5qdw]], [[5qdv]], [[5qdu]], [[5qdt]], [[5qds]], [[5qdr]], [[5qdq]], [[5qdp]], [[5qdo]], [[5qdn]], [[5qdm]], [[5qdl]], [[5qdk]], [[5qdj]], [[5qdi]], [[5qdh]], [[5qdg]], [[5qdf]] - hPTPN1B (mutant) + inhibitor<br />
+
**[[1nwl]], [[1nwe]], [[2fjm]], [[5ka3]], [[5ka7]], [[5ka9]], [[5kab]], [[5kac]], [[5kad]], [[5qde]], [[5qdf]], [[5qdg]], [[5qdh]], [[5qdi]], [[5qdj]], [[5qdk]], [[5qdl]], [[5qdm]], [[5qdn]], [[5qdo]], [[5qdp]], [[5qdq]], [[5qdr]], [[5qds]], [[5qdt]], [[5qdu]], [[5qdv]], [[5qdw]], [[5qdx]], [[5qdy]], [[5qdz]], [[5qe0]], [[5qe1]], [[5qe2]], [[5qe3]], [[5qe4]], [[5qe5]], [[5qe6]], [[5qe7]], [[5qe8]], [[5qe9]], [[5qea]], [[5qeb]], [[5qec]], [[5qed]], [[5qee]], [[5qef]], [[5qeg]], [[5qeh]], [[5qei]], [[5qej]], [[5qek]], [[5qel]], [[5qem]], [[5qen]], [[5qeo]], [[5qep]], [[5qeq]], [[5qer]], [[5qes]], [[5qet]], [[5qeu]], [[5qev]], [[5qew]], [[5qex]], [[5qey]], [[5qez]], [[5qf0]], [[5qf1]], [[5qf2]], [[5qf3]], [[5qf4]], [[5qf5]], [[5qf6]], [[5qf7]], [[5qf8]], [[5qf9]], [[5qfa]], [[5qfb]], [[5qfc]], [[5qfd]], [[5qfe]], [[5qff]], [[5qfg]], [[5qfih], [[5qfi]], [[5qfj]], [[5qfk]], [[5qfl]], [[5qfm]], [[5qfn]], [[5qfo]], [[5qfp]], [[5qfq]], [[5qfr]], [[5qfs]], [[5qft]], [[5qfu]], [[5qfv]], [[5qfw]], [[5qfx]], [[5qfy]], [[5qfz]], [[5qg0]], [[5qg1]], [[5qg2]], [[5qg3]], [[5qg4]], [[5qg5]], [[5qg6]], [[5qg7]], [[5qg8]], [[5qg9]], [[5qga]], [[5qgb]], [[5qgc]], [[5qgd]], [[5qge]], [[5qgf]], [[7fqm]], [[7fqn]], [[7fqo]], [[7fqp]], [[7fqq]], [[7fqr]], [[7fqs]], [[7fqu]], [[7fqv]], [[7fqw]], [[7fqx]], [[7fqy]], [[7fqz]], [[7frg]], [[7frh]], [[7fri]], [[7frj]], [[7frk]], [[7frl]], [[7frm]], [[7frn]], [[7fro]], [[7frp]], [[7frq]], [[7frr]], [[7gs9]], [[7gsd]], [[7gse]], [[7gsf]], [[7gsg]], [[7gsh]], [[7gsi]], [[7gsj]], [[7gsk]], [[7gsn]], [[7gsq]], [[7gsu]], [[7gsx]], [[7gsz]], [[7gt8]], [[7gtb]], [[7gtc]], [[7gtf]], [[7gtj]], [[7gtp]], [[7gtq]], [[7gtr]], [[7gts]], [[7gtv]], [[7mn7]], [[7mna]], [[7mnb]], [[7mnd]], [[7mne]], [[7mnf]], [[7mow]] - hPTP-1b catalytic domain (mutant) + inhibitor<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
**[[6xed]], [[6xeg]] – hPTPN1b + WO4<br />
**[[6xed]], [[6xeg]] – hPTPN1b + WO4<br />
**[[6xea]] – hPTPN1b + VO4<br />
**[[6xea]] – hPTPN1b + VO4<br />
-
**[[6pm8]], [[6xef]], [[7l0h]] – hPTPN1b (mutant) + VO4<br />
+
**[[6pm8]], [[6xef]], [[7l0h]] – hPTPN1b (mutant) + VO4<br />
 +
**[[7uad]] – hPTPN2 1-314 + inhibitor<br />
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
-
**[[6h8r]] – hPTPN5 + inhibitor<br />
+
**[[2cjz]] - hPTPN5 catalytic domain 258-563 (mutant) + phosphotyrosine<br />
-
**[[2cjz]] - hPTPN5 catalytic domain (mutant) 258-563 + phosphotyrosine<br />
+
**[[5ow1]], [[5ovx]], [[5ovr]] – hPTP5 catalytic domain + inhibitor<br />
**[[5ow1]], [[5ovx]], [[5ovr]] – hPTP5 catalytic domain + inhibitor<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
-
**[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]], [[6wu8]], [[7jvm]], [[7jvn]], [[7r7d]], [[7r7i]], [[7r7l]], [[7rct]], [[7vxg]] – hPTPN11 catalytic domain + inhibitor<br />
 
-
**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
 
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />
**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />
-
**[[5h08]] – hPTP ζ D1 domain + inhibitor<br />
 
**[[5bx1]] – hPTP PRL-1 + inhibitor<br />
**[[5bx1]] – hPTP PRL-1 + inhibitor<br />
-
**[[6md7]], [[6md9]], [[6mda]], [[6mdb]], [[6mdc]], [[6mdd]], [[5xzr]] - hPTP SHP-2 + inhibitor<br />
+
**[[1dg9]] – bPTP + HEPES<br />
-
**[[6crg]], [[6cms]], [[6cmr]] - hPTP SHP-2 (mutant) + inhibitor<br />
+
-
**[[1dg9]] – bPTP + HEPES<br />
+
**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />
**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />
**[[7moe]], [[7mof]], [[7mog]], [[7moh]] – AtPTP DSP1 + inhibitor<br />
**[[7moe]], [[7mof]], [[7mog]], [[7moh]] – AtPTP DSP1 + inhibitor<br />
**[[1d2a]] – yPTP + adenine <br />
**[[1d2a]] – yPTP + adenine <br />
-
**[[1d1q]] – yPTP (mutant) + PNPP<br />
+
**[[1d1q]] – yPTP (mutant) + PNPP<br />
**[[2i6p]] - SsPTP (mutant) + PNPP<br />
**[[2i6p]] - SsPTP (mutant) + PNPP<br />
**[[2i6j]] – SsPTP + phosphate<br />
**[[2i6j]] – SsPTP + phosphate<br />
-
**[[2i6m]] – SsPTP + WO4<BR />
+
**[[2i6m]] – SsPTP + WO4<br />
**[[3ido]] – EhPTP + HEPES<br />
**[[3ido]] – EhPTP + HEPES<br />
-
**[[3rgq]] – mPTP-1 + Pi(5)P<br />
+
**[[7mpd]] – SsoPTP + inhibitor – Ssccharolobus solfataricus<br />
-
**[[6h8s]] – mPTPN5 + inhibitor<br />
+
-
**[[7mpd]] – SsoPTP + inhibitor – ''Ssccharolobus solfataricus''<br />
+
**[[7mpc]] – SsoPTP + VO4<br />
**[[7mpc]] – SsoPTP + VO4<br />
-
**[[7ezn]] – PTP + VO4 – ''Cryptococcus neoformans''<br />
+
**[[7ezn]] – PTP + VO4 – Cryptococcus neoformans<br />
*Non-receptor type PTP complex with protein
*Non-receptor type PTP complex with protein
-
**[[2b4s]] - hPTP1B catalytic domain + insulin receptor<br />
+
**[[2b4s]] - hPTP-b catalytic domain + insulin receptor<br />
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />
-
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
 
-
**[[6roz]], [[6roy]] – hPTPN11 N-SH2 domain + ITSM<br />
 
-
**[[6r5g]] – hPTPN11 C-SH2 domain + ITSM<br />
 
**[[6iwd]] – hPTPN14 886-1187 + HPV18 CR3 domain<br />
**[[6iwd]] – hPTPN14 886-1187 + HPV18 CR3 domain<br />
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
-
**[[5k22]], [[6wur]] – hPTP PRL-2 (mutant) + CNNM3<br />
+
**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br />
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
**[[6nmv]], [[6nmu]], [[6nmt]], [[6nms]], [[6nmr]], [[6bit]] - hPTP SHPS-1 + antibody<br />
**[[6nmv]], [[6nmu]], [[6nmt]], [[6nms]], [[6nmr]], [[6bit]] - hPTP SHPS-1 + antibody<br />
-
**[[5lxq]] – mPTP + CNNM2<br />
+
**[[5lxq]] – mPTP PRL-1 + CNNM2<br />
 +
**[[6wus]] – mPTP PRL-1 (mutant) + CNNM2<br />
**[[5mmz]] – mPTP 4A1 + CNNM2<br />
**[[5mmz]] – mPTP 4A1 + CNNM2<br />
 +
**[[4pbv]], [[4pbw]] – cPTP CRYP-alpha1 29-316 + TrkC<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
-
*'''Yersinia tyrosine phosphatase Yop'''
+
*Non-receptor type PTP SHP-1 or tyrosine-protein phosphatase non-receptor type 6
-
**[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]], [[6xft]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br />
+
**[[3ps5]] – hPTP SHP-1 (mutant)<br />
 +
**[[1gwz]], [[2b3o]], [[4hjp]] – hPTP SHP-1 catalytic domain 242-528<br />
 +
**[[4gry]], [[4grz]], [[4hjq]] – hPTP SHP-1 catalytic domain (mutant)<br />
 +
**[[1x6c]] - hPTP SHP-1 C-terminal SH2 domain 105-220 – NMR<br />
 +
**[[2dju]], [[2edy]] – hPTP SHP-1 FN #3 domain 309-401 NMR<br />
 +
**[[2dn7]] – hPTP SHP-1 FN3 #6 domain 811-904 - NMR<br />
 +
**[[1fpr]], [[4gs0]] - hPTP SHP-1 catalytic domain + peptide<br />
 +
**[[2rmx]], [[2yu7]] – hPTP SHP-1 C-terminal SH2 domain + peptide – NMR<br />
 +
**[[6sm5]] - hPTP SHP-1 C-terminal SH2 domain + monobody<br />
 +
 
 +
*Non-receptor type PTP SHP-2 or tyrosine-protein phosphatase non-receptor type 11
 +
 
 +
**[[4dgp]] – hPTP SHP-2 SH2+catalytic domains 1-532<br />
 +
**[[2shp]], [[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]], [[5bk8]], [[6ihz]], [[6crf]], [[6cmp]] – hPTP SHP-2 SH2+catalytic domains (mutant)<br />
 +
**[[6cmq]] - hPTP SHP-2 106-529<br />
 +
**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] – hPTP SHP-2 catalytic domain 248-527<br />
 +
**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[7emn]] – hPTP SHP-2 catalytic domain (mutant)<br />
 +
**[[3tl0]], [[3tkz]], [[4qsy]], [[5df6]], [[5x7b]], [[5x94]] – hPTPN11 SH2 domain 1-220 + peptide<br />
 +
**[[6roy]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide <br />
 +
**[[6roz]] - hPTP SHP-2 N- terminal SH2 domain + ITSM peptide <br />
 +
**[[6r5g]] - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR<br />
 +
**[[7ppl]], [[7ppm]], [[7ppn]] - hPTP SHP-2 catalytic domain (mutant) + peptide<br />
 +
**[[3mow]] - hPTP SHP-2 catalytic domain + inhibitor<br />
 +
**[[3o5x]], [[4pvg]], [[4rdd]], [[5ehp]], [[5ehr]], [[5xzr]], [[6md7]], [[6md9]], [[6mda]], [[6mdb]], [[6mdc]], [[6mdd]], [[6wu8]], [[7jvm]], [[7jvn]], [[7r75]], [[7r7d]], [[7r7i]], [[7r7l]], [[7rct]], [[7vxg]], [[8b5y]], [[8cbh]], [[8t6d]], [[8u7w]], [[8u7x]] - hPTP SHP-2 SH2+catalytic domains + inhibitor<br />
 +
**[[6cmr]], [[6cms]], [[6crg]] - hPTP SHP-2 SH2+catalytic domains (mutant) + inhibitor<br />
 +
**[[8t7q]] - hPTP SHP-2 SH2+catalytic domains + drug<br />
 +
**[[4je4]], [[4jeg]] – hPTP SHP-2 N-terminal SH2 domain + monobody<br />
 +
**[[7tvj]] – hPTP SHP-2 catalytic domain 224-525 + monobody<br />
 +
 
 +
*Yersinia PTP Yop
 +
 
 +
**[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]], [[6xft]] - YePTP catalytic domain (mutant) – Yersinia enterocolitica<br />
**[[7l0i]] – YePTP (mutant) <br />
**[[7l0i]] – YePTP (mutant) <br />
**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />
**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />
Line 178: Line 186:
**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />
**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />
**[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br />
**[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br />
-
**[[1huf]] – YpPTP - ''Yersinia pestis''<br />
+
**[[1huf]] – YpPTP - Yersinia pestis<br />
**[[1qz0]] - YpPTP catalytic domain + peptide<br />
**[[1qz0]] - YpPTP catalytic domain + peptide<br />
**[[2y2f]] - YpPTP catalytic domain + inhibitor<br />
**[[2y2f]] - YpPTP catalytic domain + inhibitor<br />
Line 185: Line 193:
**[[4gf3]] – YpPTP + Yop targeting protein<br />
**[[4gf3]] – YpPTP + Yop targeting protein<br />
-
*'''Receptor-type tyrosine phosphatase'''
+
*Receptor-type PTP
**[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br />
**[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br />
Line 198: Line 206:
**[[6x38]] – DmRPTP FN5 domain<br />
**[[6x38]] – DmRPTP FN5 domain<br />
-
*'''Human receptor-type tyrosine phosphatase'''
+
*Human receptor-type PTP
**[[6uzt]] - hRPTP-α catalytic domain<br />
**[[6uzt]] - hRPTP-α catalytic domain<br />
Line 220: Line 228:
**[[6d4d]] - hRPTP-ε domain D1 residues 22-313<br />
**[[6d4d]] - hRPTP-ε domain D1 residues 22-313<br />
**[[6d4f]], [[6d3f]] - hRPTP-ε domain D2 residues 425-700<br />
**[[6d4f]], [[6d3f]] - hRPTP-ε domain D2 residues 425-700<br />
-
**[[2c7s]] - hRPTP-κ residues 865-1154<br />
+
**[[8a1f]] - hRPTP-kappa N-terminal residues 28-385<br />
-
**[[2c7s]] - hRPTP-κ residues 865-1154<br />
+
**[[2c7s]] - hRPTP-kappa residues 865-1154<br />
**[[1rpm]] - hRPTP-μ catalytic domain<br />
**[[1rpm]] - hRPTP-μ catalytic domain<br />
**[[2c9a]] - hRPTP-μ MAM-IG module<br />
**[[2c9a]] - hRPTP-μ MAM-IG module<br />
**[[2v5y]] - hRPTP-μ extracellular region<br />
**[[2v5y]] - hRPTP-μ extracellular region<br />
-
**[[2g59]], [[2gjt]], [[6suc]], [[6sub]] - hRPTP-ο catalytic domain<br />
+
**[[8a16]], [[8a17]] - hRPTP- FN#3-4 domain 478-723<br />
-
**[[2cfv]] – hRPTP-η residues 1019-1311<br />
+
**[[2g59]], [[2gjt]] - hRPTP- catalytic domain<br />
-
**[[2nz6]] - hRPTP-η residues 1019-1311 (mutant) <br />
+
**[[7u08]] - hRPTP-eta residues 37-374<br />
-
**[[2dle]] - hRPTP-η FN3 domain – NMR<BR />
+
**[[7u01]] - hRPTP-eta residues 206-364<br />
 +
**[[2cfv]] – hRPTP-eta residues 1019-1311<br />
 +
**[[2nz6]] - hRPTP-eta residues 1019-1311 (mutant) <br />
 +
**[[2dle]] - hRPTP-eta FN3 domain – NMR<BR />
**[[2qep]] – hRPTP-ν2 D1 domain<br />
**[[2qep]] – hRPTP-ν2 D1 domain<br />
**[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br />
**[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br />
Line 246: Line 257:
**[[6j6u]] - rRPTP-ζ D1-D2 domain<br />
**[[6j6u]] - rRPTP-ζ D1-D2 domain<br />
**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />
**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />
 +
**[[7xc0]] - hRPTP-H 797-1086<br />
-
*Receptor type tyrosine phosphatase complexes
+
*Receptor-type PTP complexes
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />
Line 262: Line 274:
**[[6kip]] - hRPTP-d residues 1617-1912 + liprin<br />
**[[6kip]] - hRPTP-d residues 1617-1912 + liprin<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
-
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
+
**[[3s97]] - hRPTP-zeta CA-like domain 34-302 + congtactin Ig domains<br />
-
**[[5h08]] – hPTP ζ D1 domain 1698-1993 + inhibitor<br />
+
**[[8fn8]], [[8fn9]] – hPTP zeta FN domain 310-411 + tenascin fg domain<br />
 +
**[[5h08]] – hPTP zeta D1 domain 1698-1993 + inhibitor<br />
**[[6kr4]] - hRPTP-F residues 1332-1907 + liprin<br />
**[[6kr4]] - hRPTP-F residues 1332-1907 + liprin<br />
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />
Line 274: Line 287:
**[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br />
**[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br />
-
*'''Dual-specificity tyrosine phosphatase or Dual-specificity protein phosphatase''' See [[MAP kinase phosphatase]].
+
*Dual-specificity PTP DUSP see [[Map kinase phosphatase]]
-
*'''Class II'''
 
-
*'''Low molecular weight tyrosine phosphatase (LMW-PTP)'''
+
*Class II – Low molecular weight PTP (LMW-PTP)
-
**[[1xww]], [[4z99]], [[5pnt]], [[6y2w]], [[6y2v]] - hLMW-PTP <br />
+
**[[1xww]], [[4z99]], [[5jnr]], [[5jns]], [[5jnt]] – hLMW-PTP<br />
**[[6y2v]], [[6y2w]] – hLMW-PTP (mutant) <br />
**[[6y2v]], [[6y2w]] – hLMW-PTP (mutant) <br />
-
**[[1phr]] - bLMW-PTP<br />
+
**[[1phr]] – bLMW-PTP<br />
 +
**[[5jnv]] – bLMW-PTP (mutant) <br />
 +
**[[5jnu]] – mLMW-PTP <br />
**[[7cuy]] – DmLMW-PTP <br />
**[[7cuy]] – DmLMW-PTP <br />
-
**[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR />
+
**[[1p8a]] – LMW-PTP (mutant) – Tritrichomonas foetus – NMR<br />
-
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br />
+
**[[2cwd]] – LMW-PTP – Thermus thermophilus<br />
-
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br />
+
**[[5got]] – LMW-PTP – Streptococcus pyogenes<br />
-
**[[5z3m]] – LMW-PTP – ''Vibrio cholerae''<br />
+
**[[1u2p]], [[2luo]] – MtLMW-PTP – Mycobacterium tuberculosis<br />
-
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br />
+
**[[2fek]], [[2wja]] – LMW-PTP Wzb – Escherichia coli<br />
-
**[[2oz5]] – MtLMW-PTP + inhibitor<br />
+
-
**[[2fek]], [[2wja]] – LMW-PTP Wzb – ''Escherichia coli''<br />
+
**[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br />
**[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br />
**[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br />
**[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br />
-
**[[7dhd]] – VvLMW-PTP Wzb – ''Vibrio vulnificus'' <br />
+
**[[7dhd]] – VvLMW-PTP Wzb – Vibrio vulnificus <br />
 +
**[[4egs]] – LMW-PTP N-terminal 1-146 – Thermoanaerobacter tengcongensis <br />
 +
**[[2gi4]] – LMW-PTP – Campylobacter jejuni<br />
*LMW-PTP complex
*LMW-PTP complex
-
**[[5kqg]], [[5kql]], [[5kqm]], [[5kqp]], [[7kh8]] – hLMW-PTP + inhibitor<br />
+
**[[3n8i]], [[5kqg]], [[5kql]], [[5kqm]], [[5kqp]], [[7kh8]], [[7uw6]] – hLMW-PTP + inhibitor<br />
**[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br />
**[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br />
**[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br />
**[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br />
Line 308: Line 322:
**[[7dhe]], [[7dhf]] – VvLMW-PTP Wzb + inhibitor<br />
**[[7dhe]], [[7dhf]] – VvLMW-PTP Wzb + inhibitor<br />
-
*'''Class III or M-phase inducer phosphatase 2'''
+
*For LMW-PTP from Synechocystis see [[Arsenate reductase]]
-
*'''CDC25'''
+
*Class III – CDC25 or M-phase inducer phosphatase 2
**[[1c25]] – hCDC25A catalytic domain (mutant) <br />
**[[1c25]] – hCDC25A catalytic domain (mutant) <br />

Revision as of 10:22, 15 February 2024

3D Structures of tyrosine phosphatase

Updated on 15-February-2024 - For a general description of the protein see Tyrosine phosphatase {{#tree:id=OrganizedByTopic|openlevels=0|

  • Class I
  • Non-receptor type tyrosine phosphatase; Domains – catalytic 1-321;
  • Non-receptor type PTP complex with peptide

3zmp, 3zmq, 4zrt – hPTPN1 catalytic domain + peptide

    • 4qum, 4rh5, 4rh9, 4rhg, 4s0g – hPTPN3 catalytic domain (mutant) 628-909 + peptide
    • 6hks, 6t36, 8cqy, 8oep – hPTPN3 PDZ domain 489-597 + peptide
    • 3nfk, 3nfl, 5eyz, 5ez0 - hPTPN4 PDZ domain + peptide
    • 7vze - hPTPN4 PDZ domain + papillomavirus peptide
    • 3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide
    • [[4icz, 6kzq, 6l03 – hPTPN9 catalytic domain + peptide
    • 5o2p – hPTPN12 SH3 domain/peptide
    • 3lny, 7xty - hPTPN13 PDZ2 domain 1362-1456 + peptide
    • 4gfu, 4gfv - hPTPN18 residues 6-300 + peptide
    • 4nnd - hPTPN18 residues 6-300 (mutant) + ERBB-2
    • 3brh, 3olr - hPTPN22 catalytic domain + peptide
    • 3omh - hPTPN22 catalytic domain (mutant) + peptide
    • 5crv, 5mk3, 5mk2, 5mk1, 5mk0, 5mjy – hRPTP23 domain Bro + peptide
    • 5lm1 – hRPTP23 residues 362-713 + UBAP-1 peptide
    • 3rz2 - rPTP 4A1 + peptide
    • 1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
    • 1vj6 – mPTP-BL PDZ2 domain + APC C terminal – NMR
    • 6gbe – mPTPN13 PDZ3 domain + PRK2 peptide – NMR
    • 5xw5 – yPTPN CDC14 + SWI6 peptide
    • 6g86 – yPTPN CDC14 + SIC1 peptide
    • 6g85, 6g84 – yPTPN CDC14 + CBK1 peptide
    • 2dxp, 2i6o – SsPTP (mutant) + peptide
  • Non-receptor type PTP complex with small molecule
  • Non-receptor type PTP complex with protein
    • 2b4s - hPTP-b catalytic domain + insulin receptor
    • 2gph - hPTPN7 catalytic domain (mutant) + MAPK2
    • 6iwd – hPTPN14 886-1187 + HPV18 CR3 domain
    • 5k25, 5k24, 5k23 – hPTP PRL-2 + CNNM3
    • 5k22 – hPTP PRL-2 (mutant) + CNNM3
    • 5tsr – hPTP PRL-3 (mutant) + CNNM3
    • 6nmv, 6nmu, 6nmt, 6nms, 6nmr, 6bit - hPTP SHPS-1 + antibody
    • 5lxq – mPTP PRL-1 + CNNM2
    • 6wus – mPTP PRL-1 (mutant) + CNNM2
    • 5mmz – mPTP 4A1 + CNNM2
    • 4pbv, 4pbw – cPTP CRYP-alpha1 29-316 + TrkC
    • 4zj7 – yPTPN CDC14 C terminal + importin
    • 1g4u – StPTP + RAS-related C3 botulinum toxin substrate
    • 1jyo – StPTP + secretion chaperone SICP
  • Non-receptor type PTP SHP-1 or tyrosine-protein phosphatase non-receptor type 6
    • 3ps5 – hPTP SHP-1 (mutant)
    • 1gwz, 2b3o, 4hjp – hPTP SHP-1 catalytic domain 242-528
    • 4gry, 4grz, 4hjq – hPTP SHP-1 catalytic domain (mutant)
    • 1x6c - hPTP SHP-1 C-terminal SH2 domain 105-220 – NMR
    • 2dju, 2edy – hPTP SHP-1 FN #3 domain 309-401 NMR
    • 2dn7 – hPTP SHP-1 FN3 #6 domain 811-904 - NMR
    • 1fpr, 4gs0 - hPTP SHP-1 catalytic domain + peptide
    • 2rmx, 2yu7 – hPTP SHP-1 C-terminal SH2 domain + peptide – NMR
    • 6sm5 - hPTP SHP-1 C-terminal SH2 domain + monobody
  • Non-receptor type PTP SHP-2 or tyrosine-protein phosphatase non-receptor type 11
  • Yersinia PTP Yop
    • 1yts, 4yaa, 4z6b, 4zi4, 4zn5, 6xft - YePTP catalytic domain (mutant) – Yersinia enterocolitica
    • 7l0i – YePTP (mutant)
    • 1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
    • 2i42, 7l0m – YePTP (mutant) + VO4
    • 1ypt, 1ytw – YePTP catalytic domain + WO4
    • 1ytn - YePTP catalytic domain + NO3
    • 1lyv - YePTP catalytic domain (mutant) + phosphate
    • 1pa9, 3bm8 - YePTP catalytic domain (mutant) + inhibitor
    • 3u96 - YePTP catalytic domain (mutant) + PNCS
    • 1huf – YpPTP - Yersinia pestis
    • 1qz0 - YpPTP catalytic domain + peptide
    • 2y2f - YpPTP catalytic domain + inhibitor
    • 1k46 - YpPTP N terminal domain
    • 1m0v - YpPTP N terminal domain + peptide – NMR
    • 4gf3 – YpPTP + Yop targeting protein
  • Receptor-type PTP
    • 1yfo, 2i1y – mRPTP-α catalytic domain
    • 1p15 - mRPTP-α D2 domain
    • 3pxh - mRPTP Ig domains
    • 1jln, 2a8b - mRPTP-R catalytic domain
    • 3sr9 - mRPTP-σ residues 1326 – 1901
    • 2nv5 – rRPRP
    • 2yd4 - cRPTP-σ Ig1-2 domain – chicken
    • 2yd1, 2yd2, 3pxj – DmRPTP Ig1-2 domain – Drosophila melanogaster
    • 3s3e – DmRPTP-10D catalytic domain
    • 6x38 – DmRPTP FN5 domain
  • Human receptor-type PTP
    • 6uzt - hRPTP-α catalytic domain
    • 2ahs – hRPTP-β
    • 2i3r, 2i5x - hRPTP-β catalytic domain
    • 2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
    • 2h4v, 2pbn, 3qcb – hRPTP-γ domain 1
    • 3qcn - hRPTP-γ domain 1 (mutant)
    • 2nlk - hRPTP-γ catalytic domain
    • 3jxh - hRPTP-γ CA-like domain
    • 5fmv - hRPTP-γ domain D1-D4
    • 5fn6 - hRPTP-γ domain D1-D3
    • 5fn7 - hRPTP-γ domain D1-D2
    • 5fn8 - rRPTP-γ domain D3-D4
    • 4yfe - hRPTP-δ FN1-FN2 domain 321-511
    • 4yfg - hRPTP-δ Ig1-FN1 domain 21-501
    • 2dlh, 1x5z - hRPTP-δ FN3 domain 405-514 – NMR
    • 2yd6, 2yd7 - hRPTP-δ Ig1-2 domain 21-220
    • 6x3a - hRPTP-δ FN4-FN6 domain 607-916
    • 2jjd - hRPTP-ε residues 107-697
    • 6d4d - hRPTP-ε domain D1 residues 22-313
    • 6d4f, 6d3f - hRPTP-ε domain D2 residues 425-700
    • 8a1f - hRPTP-kappa N-terminal residues 28-385
    • 2c7s - hRPTP-kappa residues 865-1154
    • 1rpm - hRPTP-μ catalytic domain
    • 2c9a - hRPTP-μ MAM-IG module
    • 2v5y - hRPTP-μ extracellular region
    • 8a16, 8a17 - hRPTP- FN#3-4 domain 478-723
    • 2g59, 2gjt - hRPTP- catalytic domain
    • 7u08 - hRPTP-eta residues 37-374
    • 7u01 - hRPTP-eta residues 206-364
    • 2cfv – hRPTP-eta residues 1019-1311
    • 2nz6 - hRPTP-eta residues 1019-1311 (mutant)
    • 2dle - hRPTP-eta FN3 domain – NMR
    • 2qep – hRPTP-ν2 D1 domain
    • 4hti, 4htj – hRPTP-ν2 membrane proximal ectodomain
    • 2ooq – hRPTP-ρ
    • 2fh7, 4bpc - hRPTP-σ catalytic domain (mutant)
    • 2yd9 - hRPTP-σ Ig1-3 domain (mutant)
    • 2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
    • 4pbx - hRPTP-σ residues 30-588
    • 3jxf - hRPTP-ζ CA-like domain
    • 5awx - hRPTP-ζ D1 domain
    • 2qt7, 3n01, 3n4w, 3ng8, 3np5 – hRPTP IA-2
    • 6tpv - hRPTP-F 1st-2nd FN3 domain 319-512
    • 6tpu, 6tpt - hRPTP-F 3rd-4th FN3 domain 513-705
    • 4n5u - hRPTP-F 4th FN3 domain 601-705
    • 2edx - hRPTP-F 4th FN3 domain – NMR
    • 6tpw - hRPTP-F 1st-4th FN3 domain
    • 6j6u - rRPTP-ζ D1-D2 domain
    • 3jxg, 3jxh - mRPTP-γ CA-like domain
    • 7xc0 - hRPTP-H 797-1086
  • Receptor-type PTP complexes
    • 2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
    • 2h03 - hRPTP-β catalytic domain (mutant) + inhibitor
    • 2hy3, 3qcc, 3qcd - hRPTP-γ domain 1 + VO4
    • 3qce, 3qcf, 3qcg, 3qch, 3qci, 3qcj, 3qck - hRPTP-γ domain 1 + inhibitor
    • 3qcl, 3qcm - hRPTP-γ domain 1 (mutant) + inhibitor
    • 5e5r - hRPTP-γ domain CA + contactin 3
    • 4rca, 4y61 - hRPTP-δ Ig1-Ig2 domain 21-318 + SLITRK1
    • 5xnp - hRPTP-δ Ig1-Ig2 domain (mutant) + SALM5
    • 6kip - hRPTP-δ residues 1617-1912 + liprin
    • 5y32, 4yfd, 4yh7, 5wy8 - hRPTP-δ Ig1-Ig2 domain + IL1RAPL1
    • 5xnp - hRPTP-d Ig1-Ig2 domain (mutant) + SALM5
    • 6kip - hRPTP-d residues 1617-1912 + liprin
    • 2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
    • 3s97 - hRPTP-zeta CA-like domain 34-302 + congtactin Ig domains
    • 8fn8, 8fn9 – hPTP zeta FN domain 310-411 + tenascin fg domain
    • 5h08 – hPTP zeta D1 domain 1698-1993 + inhibitor
    • 6kr4 - hRPTP-F residues 1332-1907 + liprin
    • 1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide
    • 5e5u - mRPTP-γ domain CA + contactin 6
    • 3kld - mRPTP-γ CA-like domain + contactin 4
    • 5xwu - mRPTP- Ig1-Ig3 domain + LRR-IG
    • 5xwt - mRPTP- Ig1-FN1 domain + LRR-IG
    • 3s3f - DmRPTP-10D catalytic domain + VO4
    • 3s3h - DmRPTP-10D catalytic domain + peptide
    • 3s3k - DmRPTP-10D catalytic domain + inhibitor


  • Class II – Low molecular weight PTP (LMW-PTP)
    • 1xww, 4z99, 5jnr, 5jns, 5jnt – hLMW-PTP
    • 6y2v, 6y2w – hLMW-PTP (mutant)
    • 1phr – bLMW-PTP
    • 5jnv – bLMW-PTP (mutant)
    • 5jnu – mLMW-PTP
    • 7cuy – DmLMW-PTP
    • 1p8a – LMW-PTP (mutant) – Tritrichomonas foetus – NMR
    • 2cwd – LMW-PTP – Thermus thermophilus
    • 5got – LMW-PTP – Streptococcus pyogenes
    • 1u2p, 2luo – MtLMW-PTP – Mycobacterium tuberculosis
    • 2fek, 2wja – LMW-PTP Wzb – Escherichia coli
    • 4eti, 4etm, 4kk3 – BsLMW-PTP
    • 4etn, 4kk4 – BsLMW-PTP (mutant)
    • 7dhd – VvLMW-PTP Wzb – Vibrio vulnificus
    • 4egs – LMW-PTP N-terminal 1-146 – Thermoanaerobacter tengcongensis
    • 2gi4 – LMW-PTP – Campylobacter jejuni
  • LMW-PTP complex
    • 3n8i, 5kqg, 5kql, 5kqm, 5kqp, 7kh8, 7uw6 – hLMW-PTP + inhibitor
    • 4z9a – hLMW-PTP + phenylmethanesulfonic acid
    • 4z9b – hLMW-PTP + benzylphosphonic acid
    • 1z12 - bLMW-PTP + VO4
    • 1z13 - bPTP + MoO4
    • 5jnw – bLMW-PTP + inhibitor
    • 3rof – LMW-PTP-A + peptide – Staphylococcus aureus
    • 1u2q – MtLMW-PTP + glycerol
    • 2oz5 – MtLMW-PTP + inhibitor
    • 7dhe, 7dhf – VvLMW-PTP Wzb + inhibitor
  • Class III – CDC25 or M-phase inducer phosphatase 2
    • 1c25 – hCDC25A catalytic domain (mutant)
    • 1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
    • 2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
    • 4wh7 - hCDC25B catalytic domain (mutant) + ligand
    • 4wh9 - hCDC25B catalytic domain (mutant) + inhibitor
    • 1cwr, 1cws - hCDC25B catalytic domain + WO4
    • 1cwt - hCDC25B catalytic domain + Methyl-Hg
    • 3op3 – hCDC25C residues 270-462
  • Class IV
    • 4tvv – PTP – Legionella pneumophila
  • T-cell tyrosine phosphatase
  • Other tyrosine phosphatases
    • 4az1 – PTP – Trypanosoma cruzi
    • 4r0s – PaPTP – Pseudomonas aeruginosa
    • 4r0t – PaPTP (mutant) + tyrosine
    • 5ncr – PTP (mutant) – ORF virus

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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