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1hdf

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{{STRUCTURE_1hdf| PDB=1hdf | SCENE= }}
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'''EVOLUTION OF THE EYE LENS BETA-GAMMA-CRYSTALLIN DOMAIN FOLD'''
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===EVOLUTION OF THE EYE LENS BETA-GAMMA-CRYSTALLIN DOMAIN FOLD===
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==Overview==
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BACKGROUND: The betagamma-crystallins belong to a superfamily of two-domain proteins found in vertebrate eye lenses, with distant relatives occurring in microorganisms. It has been considered that an eukaryotic stress protein, spherulin 3a, from the slime mold Physarum polycephalum shares a common one-domain ancestor with crystallins, similar to the one-domain 3-D structure determined by NMR. RESULTS: The X-ray structure of spherulin 3a shows it to be a tight homodimer, which is consistent with ultracentrifugation studies. The (two-motif) domain fold contains a pair of calcium binding sites very similar to those found in a two-domain prokaryotic betagamma-crystallin fold family member, Protein S. Domain pairing in the spherulin 3a dimer is two-fold symmetric, but quite different in character from the pseudo-two-fold pairing of domains in betagamma-crystallins. There is no evidence that the spherulin 3a single domain can fold independently of its partner domain, a feature that may be related to the absence of a tyrosine corner. CONCLUSION: Although it is accepted that the vertebrate two-domain betagamma-crystallins evolved from a common one-domain ancestor, the mycetezoan single-domain spherulin 3a, with its unique mode of domain pairing, is likely to be an evolutionary offshoot, perhaps from as far back as the one-motif ancestral stage. The spherulin 3a protomer stability appears to be dependent on domain pairing. Spherulin-like domain sequences that are found within bacterial proteins associated with virulence are likely to bind calcium.
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{{ABSTRACT_PUBMED_11250196}}
==About this Structure==
==About this Structure==
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[[Category: Spherulin 3a]]
[[Category: Spherulin 3a]]
[[Category: Tyrosine corner]]
[[Category: Tyrosine corner]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:01:48 2008''

Revision as of 05:01, 1 July 2008

Image:1hdf.png

Template:STRUCTURE 1hdf

EVOLUTION OF THE EYE LENS BETA-GAMMA-CRYSTALLIN DOMAIN FOLD

Template:ABSTRACT PUBMED 11250196

About this Structure

1HDF is a Single protein structure of sequence from Physarum polycephalum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the calcium-loaded spherulin 3a dimer sheds light on the evolution of the eye lens betagamma-crystallin domain fold., Clout NJ, Kretschmar M, Jaenicke R, Slingsby C, Structure. 2001 Feb 7;9(2):115-24. PMID:11250196

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