1he9

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{{STRUCTURE_1he9| PDB=1he9 | SCENE= }}
{{STRUCTURE_1he9| PDB=1he9 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''
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===CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN===
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==Overview==
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Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.
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(as it appears on PubMed at http://www.pubmed.gov), where 11226412 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11226412}}
==About this Structure==
==About this Structure==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Virulence factor]]
[[Category: Virulence factor]]
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Revision as of 05:04, 1 July 2008

Image:1he9.png

Template:STRUCTURE 1he9

CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN

Template:ABSTRACT PUBMED 11226412

About this Structure

1HE9 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structure of the ExoS GTPase activating domain., Wurtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E, FEBS Lett. 2001 Feb 23;491(1-2):26-9. PMID:11226412

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