7xqe
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039== | |
| - | + | <StructureSection load='7xqe' size='340' side='right'caption='[[7xqe]], [[Resolution|resolution]] 2.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XQE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4I:2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide'>H4I</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xqe OCA], [https://pdbe.org/7xqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xqe RCSB], [https://www.ebi.ac.uk/pdbsum/7xqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xqe ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Li | + | == Function == |
| - | [[Category: Xu | + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. |
| - | [[Category: Zhang | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li C]] | ||
| + | [[Category: Wu X]] | ||
| + | [[Category: Xu Y]] | ||
| + | [[Category: Zhang Y]] | ||
Revision as of 05:34, 31 May 2023
Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039
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Categories: Homo sapiens | Large Structures | Li C | Wu X | Xu Y | Zhang Y
