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7xs4

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'''Unreleased structure'''
 
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The entry 7xs4 is ON HOLD until Paper Publication
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==Crystal structure of URT1 in complex with AAAU RNA==
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<StructureSection load='7xs4' size='340' side='right'caption='[[7xs4]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors: Hu, Q., Zhu, L.R., lv, M.Q., Gong, Q.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xs4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XS4 FirstGlance]. <br>
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Description: Crystal structure of URT1 in complex with AAAU RNA
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xs4 OCA], [https://pdbe.org/7xs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xs4 RCSB], [https://www.ebi.ac.uk/pdbsum/7xs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xs4 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Hu, Q]]
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== Function ==
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[[Category: Gong, Q.G]]
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[[https://www.uniprot.org/uniprot/URT1_ARATH URT1_ARATH]] UTP:RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides (PubMed:23748567, PubMed:25928405). Uridylates oligo(A)-tailed mRNAs to prevent 3' to 5' ribonucleotytic attacks (PubMed:23748567). Can prevent the 3' trimming of mRNAs still engaged on polysomes (PubMed:23748567). Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341). URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405). URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405). Has no effect on uridylation of heterochromatic siRNAs (PubMed:25928341). Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:25928405).<ref>PMID:23748567</ref> <ref>PMID:25928341</ref> <ref>PMID:25928405</ref>
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[[Category: Lv, M.Q]]
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== References ==
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[[Category: Zhu, L.R]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Gong QG]]
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[[Category: Hu Q]]
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[[Category: Zhu LR]]
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[[Category: Lv MQ]]

Revision as of 07:42, 21 September 2022

Crystal structure of URT1 in complex with AAAU RNA

PDB ID 7xs4

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