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1hfc

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{{STRUCTURE_1hfc| PDB=1hfc | SCENE= }}
{{STRUCTURE_1hfc| PDB=1hfc | SCENE= }}
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'''1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE'''
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===1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE===
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==Overview==
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The X-ray crystal structure of a 19 kDa active fragment of human fibroblast collagenase has been determined by the multiple isomorphous replacement method and refined at 1.56 A resolution to an R-factor of 17.4%. The current structure includes a bound hydroxamate inhibitor, 88 waters and three metal atoms (two zincs and a calcium). The overall topology of the enzyme, comprised of a five stranded beta-sheet and three alpha-helices, is similar to the thermolysin-like metalloproteinases. There are some important differences between the collagenase and thermolysin families of enzymes. The active site zinc ligands are all histidines (His-218, His-222, and His-228). The presence of a second zinc ion in a structural role is a unique feature of the matrix metalloproteinases. The binding properties of the active site cleft are more dependent on the main chain conformation of the enzyme (and substrate) compared with thermolysin. A mechanism of action for peptide cleavage similar to that of thermolysin is proposed for fibroblast collagenase.
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(as it appears on PubMed at http://www.pubmed.gov), where 8090713 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8090713}}
==About this Structure==
==About this Structure==
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[[Category: Spurlino, J C.]]
[[Category: Spurlino, J C.]]
[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:06:42 2008''

Revision as of 05:06, 1 July 2008

Image:1hfc.png

Template:STRUCTURE 1hfc

1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE

Template:ABSTRACT PUBMED 8090713

About this Structure

1HFC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.56 A structure of mature truncated human fibroblast collagenase., Spurlino JC, Smallwood AM, Carlton DD, Banks TM, Vavra KJ, Johnson JS, Cook ER, Falvo J, Wahl RC, Pulvino TA, et al., Proteins. 1994 Jun;19(2):98-109. PMID:8090713

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