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7nsk
From Proteopedia
(Difference between revisions)
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==Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand== | ==Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand== | ||
| - | <StructureSection load='7nsk' size='340' side='right'caption='[[7nsk]]' scene=''> | + | <StructureSection load='7nsk' size='340' side='right'caption='[[7nsk]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NSK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NSK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nsk OCA], [https://pdbe.org/7nsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nsk RCSB], [https://www.ebi.ac.uk/pdbsum/7nsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nsk ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4G:1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE'>P4G</scene>, <scene name='pdbligand=UQE:(2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide'>UQE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nsk OCA], [https://pdbe.org/7nsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nsk RCSB], [https://www.ebi.ac.uk/pdbsum/7nsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nsk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Giastas P]] | [[Category: Giastas P]] | ||
[[Category: Mpakali A]] | [[Category: Mpakali A]] | ||
[[Category: Stratikos E]] | [[Category: Stratikos E]] | ||
Current revision
Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand
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