3rio

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<StructureSection load='3rio' size='340' side='right'caption='[[3rio]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='3rio' size='340' side='right'caption='[[3rio]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU13880, glcT, ykwA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rio OCA], [https://pdbe.org/3rio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rio RCSB], [https://www.ebi.ac.uk/pdbsum/3rio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rio ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rio OCA], [https://pdbe.org/3rio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rio RCSB], [https://www.ebi.ac.uk/pdbsum/3rio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rio ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GLCT_BACSU GLCT_BACSU]] Mediates the positive regulation of the glucose PTS operon (ptsGHI) by functioning as an antiterminator factor of transcription via its interaction with the RNA-antiterminator (RAT) sequence located upstream of the ptsG gene. The RNA-binding domain of GlcT directly binds to the RNA antiterminator (RAT) sequence and prevents transcriptional termination. GlcT binding requires two identical and nearly symmetrical triple base pairings in the RAT sequence.<ref>PMID:11902727</ref> <ref>PMID:9765562</ref>
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[https://www.uniprot.org/uniprot/GLCT_BACSU GLCT_BACSU] Mediates the positive regulation of the glucose PTS operon (ptsGHI) by functioning as an antiterminator factor of transcription via its interaction with the RNA-antiterminator (RAT) sequence located upstream of the ptsG gene. The RNA-binding domain of GlcT directly binds to the RNA antiterminator (RAT) sequence and prevents transcriptional termination. GlcT binding requires two identical and nearly symmetrical triple base pairings in the RAT sequence.<ref>PMID:11902727</ref> <ref>PMID:9765562</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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GlcT is a transcriptional antiterminator protein that is involved in regulation of glucose metabolism in Bacillus subtilis. Antiterminator proteins bind specific RNA sequences, thus preventing the formation of overlapping terminator stem-loops. The structure of a fragment (residues 3-170) comprising the RNA-binding domain (RBD) and the first regulatory domain (PRDI) of GlcT was solved at 2.0 A resolution with one molecule in the asymmetric unit. The two domains are connected by a helical linker. Their interface is mostly constituted by hydrophobic interactions.
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Structure of the RBD-PRDI fragment of the antiterminator protein GlcT.,Himmel S, Grosse C, Wolff S, Schwiegk C, Becker S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):751-6. Epub, 2012 Jun 22. PMID:22750856<ref>PMID:22750856</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rio" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Becker, S]]
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[[Category: Becker S]]
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[[Category: Grosse, C]]
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[[Category: Grosse C]]
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[[Category: Himmel, S]]
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[[Category: Himmel S]]
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[[Category: Wolff, S]]
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[[Category: Wolff S]]
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[[Category: Four helix bundle]]
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[[Category: Transcription]]
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[[Category: Transcriptional antitermination]]
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[[Category: Twisted beta sheet]]
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Current revision

Crystal structure of GlcT CAT-PRDI

PDB ID 3rio

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OCA

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