3rmh

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<StructureSection load='3rmh' size='340' side='right'caption='[[3rmh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3rmh' size='340' side='right'caption='[[3rmh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RMH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RMH FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0G05588g ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.902&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rmh OCA], [https://pdbe.org/3rmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rmh RCSB], [https://www.ebi.ac.uk/pdbsum/3rmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rmh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rmh OCA], [https://pdbe.org/3rmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rmh RCSB], [https://www.ebi.ac.uk/pdbsum/3rmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rmh ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6FT40_CANGA Q6FT40_CANGA]
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The budding yeast Cdc13-Stn1-Ten1 complex is crucial for telomere protection and has been proposed to resemble structurally and functionally the RPA complex. The Cdc13 homologues in Candida species are unusually small and lack two conserved domains previously implicated in telomere regulation, thus raising interesting questions concerning the mechanisms and evolution of these proteins. In this report, we show that the unusually small Cdc13 homologue in C. albicans is indeed a regulator of telomere lengths, and that it associates with telomere DNA in vivo. We demonstrated high affinity telomere DNA-binding by C. tropicalis Cdc13 (CtCdc13), and found that dimerization of this protein through its OB4 domain is important for high affinity DNA binding. Interestingly, CtCdc13-DNA complex formation appears to involve primarily recognition of multiple copies of a six-nucleotide element (GGATGT) that is shared by many Candida telomere repeats. We also determined the crystal structure of the OB4 domain of C. glabrata Cdc13, which revealed a novel mechanism of OB fold dimerization. The structure also exhibits marked differences to the C-terminal OB fold of RPA70, thus arguing against a close evolutionary kinship between these two proteins. Our findings provide new insights on the mechanisms and evolution of a critical telomere end binding protein.
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Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA-binding, and substantial structural differences between Cdc13 and RPA70.,Yu EY, Sun J, Lei M, Lue NF Mol Cell Biol. 2011 Oct 24. PMID:22025677<ref>PMID:22025677</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rmh" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 2001]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lei, M]]
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[[Category: Lei M]]
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[[Category: Sun, J]]
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[[Category: Sun J]]
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[[Category: Yang, Y]]
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[[Category: Yang Y]]
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[[Category: Dimer]]
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[[Category: Dimeric complex]]
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[[Category: Ob fold]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of yeast telomere protein Cdc13 OB4

PDB ID 3rmh

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OCA

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