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3rzl

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Current revision (17:21, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3rzl' size='340' side='right'caption='[[3rzl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3rzl' size='340' side='right'caption='[[3rzl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rzg|3rzg]], [[3rzh|3rzh]], [[3rzj|3rzj]], [[3rzk|3rzk]], [[3rzm|3rzm]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALKBH2, ABH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzl OCA], [https://pdbe.org/3rzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzl RCSB], [https://www.ebi.ac.uk/pdbsum/3rzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzl OCA], [https://pdbe.org/3rzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzl RCSB], [https://www.ebi.ac.uk/pdbsum/3rzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
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[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, B]]
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[[Category: Chen B]]
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[[Category: Dinner, A]]
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[[Category: Dinner A]]
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[[Category: He, C]]
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[[Category: He C]]
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[[Category: Jia, G]]
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[[Category: Jia G]]
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[[Category: Li, C]]
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[[Category: Li C]]
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[[Category: Qi, B]]
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[[Category: Qi B]]
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[[Category: Yang, C]]
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[[Category: Yang C]]
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[[Category: Yi, C]]
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[[Category: Yi C]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Demethylase]]
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[[Category: Jelly-roll]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase-dna complex]]
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[[Category: Protein-dna complex]]
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Current revision

Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage

PDB ID 3rzl

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