8d04
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Hallucinated C2 protein assembly HALC2_062== | |
| + | <StructureSection load='8d04' size='340' side='right'caption='[[8d04]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8d04]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D04 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d04 OCA], [https://pdbe.org/8d04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d04 RCSB], [https://www.ebi.ac.uk/pdbsum/8d04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d04 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Deep learning generative approaches provide an opportunity to broadly explore protein structure space beyond the sequences and structures of natural proteins. Here we use deep network hallucination to generate a wide range of symmetric protein homo-oligomers given only a specification of the number of protomers and the protomer length. Crystal structures of 7 designs are very close to the computational models (median RMSD: 0.6 A), as are 3 cryoEM structures of giant 10 nanometer rings with up to 1550 residues and C33 symmetry; all differ considerably from previously solved structures. Our results highlight the rich diversity of new protein structures that can be generated using deep learning, and pave the way for the design of increasingly complex components for nanomachines and biomaterials. | ||
| - | + | Hallucinating symmetric protein assemblies.,Wicky BIM, Milles LF, Courbet A, Ragotte RJ, Dauparas J, Kinfu E, Tipps S, Kibler RD, Baek M, DiMaio F, Li X, Carter L, Kang A, Nguyen H, Bera AK, Baker D Science. 2022 Sep 15:eadd1964. doi: 10.1126/science.add1964. PMID:36108048<ref>PMID:36108048</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8d04" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Baker D]] | ||
| + | [[Category: Bera AK]] | ||
| + | [[Category: Milles LF]] | ||
| + | [[Category: Ragotte RJ]] | ||
| + | [[Category: Wicky BIM]] | ||
Revision as of 06:23, 28 September 2022
Hallucinated C2 protein assembly HALC2_062
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