1hk9

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{{STRUCTURE_1hk9| PDB=1hk9 | SCENE= }}
{{STRUCTURE_1hk9| PDB=1hk9 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HFQ PROTEIN FROM ESCHERICHIA COLI'''
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===CRYSTAL STRUCTURE OF THE HFQ PROTEIN FROM ESCHERICHIA COLI===
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==Overview==
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The Hfq protein was discovered in Escherichia coli in the early seventies as a host factor for the Qbeta phage RNA replication. During the last decade, it was shown to be involved in many RNA processing events and remote sequence homology indicated a link to spliceosomal Sm proteins. We report the crystal structure of the E.coli Hfq protein showing that its monomer displays a characteristic Sm-fold and forms a homo-hexamer, in agreement with former biochemical data. Overall, the structure of the E.coli Hfq ring is similar to the one recently described for Staphylococcus aureus. This confirms that bacteria contain a hexameric Sm-like protein which is likely to be an ancient and less specialized form characterized by a relaxed RNA binding specificity. In addition, we identified an Hfq ortholog in the archaeon Methanococcus jannaschii which lacks a classical Sm/Lsm gene. Finally, a detailed structural comparison shows that the Sm-fold is remarkably well conserved in bacteria, Archaea and Eukarya, and represents a universal and modular building unit for oligomeric RNA binding proteins.
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{{ABSTRACT_PUBMED_12853626}}
==About this Structure==
==About this Structure==
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[[Category: Rna chaperone]]
[[Category: Rna chaperone]]
[[Category: Sm-like]]
[[Category: Sm-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:56:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:18:21 2008''

Revision as of 05:18, 1 July 2008

Image:1hk9.png

Template:STRUCTURE 1hk9

CRYSTAL STRUCTURE OF THE HFQ PROTEIN FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 12853626

About this Structure

1HK9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Sm-like proteins in Eubacteria: the crystal structure of the Hfq protein from Escherichia coli., Sauter C, Basquin J, Suck D, Nucleic Acids Res. 2003 Jul 15;31(14):4091-8. PMID:12853626

Page seeded by OCA on Tue Jul 1 08:18:21 2008

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