7wm3

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==hnRNP A2/B1 RRMs in complex with single-stranded DNA==
==hnRNP A2/B1 RRMs in complex with single-stranded DNA==
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<StructureSection load='7wm3' size='340' side='right'caption='[[7wm3]]' scene=''>
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<StructureSection load='7wm3' size='340' side='right'caption='[[7wm3]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WM3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wm3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WM3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wm3 OCA], [https://pdbe.org/7wm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wm3 RCSB], [https://www.ebi.ac.uk/pdbsum/7wm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wm3 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wm3 OCA], [https://pdbe.org/7wm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wm3 RCSB], [https://www.ebi.ac.uk/pdbsum/7wm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wm3 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ROA2_HUMAN ROA2_HUMAN] Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ROA2_HUMAN ROA2_HUMAN] Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been identified as a nuclear DNA sensor. Upon viral infection, hnRNP A2/B1 recognizes pathogen-derived DNA as a homodimer, which is a prerequisite for its translocation to the cytoplasm to activate the interferon response. However, the DNA binding mechanism inducing hnRNP A2/B1 homodimerization is unknown. Here, we show the crystal structure of the RNA recognition motif (RRM) of hnRNP A2/B1 in complex with a U-shaped ssDNA, which mediates the formation of a newly observed protein dimer. Our biochemical assays and mutagenesis studies confirm that the hnRNP A2/B1 homodimer forms in solution by binding to pre-generated ssDNA or dsDNA with a U-shaped bulge. These results depict a potential functional state of hnRNP A2/B1 in antiviral immunity and other cellular processes.
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Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.,Liu Y, Abula A, Xiao H, Guo H, Li T, Zheng L, Chen B, Nguyen HC, Ji X J Mol Biol. 2022 Dec 14;435(3):167920. doi: 10.1016/j.jmb.2022.167920. PMID:36528084<ref>PMID:36528084</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7wm3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abula, A, Liu, Y, Guo, H, Li, T, Ji, X]]
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[[Category: Abula A]]
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[[Category: Guo H]]
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[[Category: Ji X]]
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[[Category: Li T]]
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[[Category: Liu Y]]

Revision as of 07:48, 11 January 2023

hnRNP A2/B1 RRMs in complex with single-stranded DNA

PDB ID 7wm3

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