1hkf

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[[Image:1hkf.gif|left|200px]]
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{{Seed}}
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[[Image:1hkf.png|left|200px]]
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{{STRUCTURE_1hkf| PDB=1hkf | SCENE= }}
{{STRUCTURE_1hkf| PDB=1hkf | SCENE= }}
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'''THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY'''
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===THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY===
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==Overview==
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Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
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The line below this paragraph, {{ABSTRACT_PUBMED_12791260}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12791260 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791260}}
==About this Structure==
==About this Structure==
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[[Category: Natural cytotoxicity receptor]]
[[Category: Natural cytotoxicity receptor]]
[[Category: Nkp44,receptor]]
[[Category: Nkp44,receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:56:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:18:46 2008''

Revision as of 05:18, 1 July 2008

Image:1hkf.png

Template:STRUCTURE 1hkf

THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY

Template:ABSTRACT PUBMED 12791260

About this Structure

1HKF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity., Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D, Structure. 2003 Jun;11(6):725-34. PMID:12791260

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