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7t5y

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Current revision (17:00, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7t5y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7t5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7t5k|7t5k]], [[7t6c|7t6c]], [[7t6h|7t6h]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref>
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[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7t5y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7t5y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ambarian, J A]]
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[[Category: Ambarian JA]]
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[[Category: Davis, K M]]
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[[Category: Davis KM]]
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[[Category: Horwitz, S M]]
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[[Category: Horwitz SM]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ

PDB ID 7t5y

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