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7wt2

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Current revision (17:44, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7wt2' size='340' side='right'caption='[[7wt2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='7wt2' size='340' side='right'caption='[[7wt2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7wt2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WT2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WT2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ZO:(~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic+acid'>5ZO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ZO:(~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic+acid'>5ZO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wt2 OCA], [https://pdbe.org/7wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/7wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wt2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wt2 OCA], [https://pdbe.org/7wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/7wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wt2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7wt2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7wt2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lactoylglutathione lyase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Usami, M]]
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[[Category: Usami M]]
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[[Category: Yokoyama, H]]
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[[Category: Yokoyama H]]
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[[Category: Glyoxalase i]]
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[[Category: Lyase]]
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[[Category: Zinc metalloenzyme]]
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Current revision

human glyoxalase I in complex with TLSC702

PDB ID 7wt2

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OCA

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