3sbw

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<StructureSection load='3sbw' size='340' side='right'caption='[[3sbw]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='3sbw' size='340' side='right'caption='[[3sbw]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sbw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SBW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sbw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SBW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sbw OCA], [https://pdbe.org/3sbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sbw RCSB], [https://www.ebi.ac.uk/pdbsum/3sbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sbw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sbw OCA], [https://pdbe.org/3sbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sbw RCSB], [https://www.ebi.ac.uk/pdbsum/3sbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sbw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
==See Also==
==See Also==
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Cao, E]]
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[[Category: Cao E]]
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[[Category: Lazar-Molnar, E]]
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[[Category: Lazar-Molnar E]]
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[[Category: Nathenson, S G]]
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[[Category: Nathenson SG]]
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[[Category: Ramagopal, U A]]
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[[Category: Ramagopal UA]]
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[[Category: B7-h1]]
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[[Category: Complex]]
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[[Category: Costimulatory]]
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[[Category: Immune system]]
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[[Category: Pd-1]]
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[[Category: Pd-l1]]
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[[Category: Programmed death-1 ligand 1]]
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Current revision

Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and human PD-L1

PDB ID 3sbw

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