3svf
From Proteopedia
(Difference between revisions)
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<StructureSection load='3svf' size='340' side='right'caption='[[3svf]], [[Resolution|resolution]] 1.98Å' scene=''> | <StructureSection load='3svf' size='340' side='right'caption='[[3svf]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3svf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3svf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SVF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WDR:(4S)-6-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-4-(2-HYDROXYETHOXY)-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>WDR</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.975Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WDR:(4S)-6-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-4-(2-HYDROXYETHOXY)-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>WDR</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svf OCA], [https://pdbe.org/3svf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3svf RCSB], [https://www.ebi.ac.uk/pdbsum/3svf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3svf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svf OCA], [https://pdbe.org/3svf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3svf RCSB], [https://www.ebi.ac.uk/pdbsum/3svf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3svf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Edwards | + | [[Category: Felletar I]] |
| - | [[Category: Felletar | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Filippakopoulos | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Picaud S]] |
| - | [[Category: Picaud | + | [[Category: Weigelt J]] |
| - | + | [[Category: Von Delft F]] | |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand
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