DNA mismatch repair protein
From Proteopedia
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'''DNA mismatch repair proteins''' are key players in genomic stability by signalling mismatches occurring during DNA replication and recombination<ref>PMID:21638687</ref> .<br/> | '''DNA mismatch repair proteins''' are key players in genomic stability by signalling mismatches occurring during DNA replication and recombination<ref>PMID:21638687</ref> .<br/> | ||
| - | '''MutS''' is prokaryotic and recognizes base-base mismatches and small insertion/deletion mispairs.<br /> | + | '''MutS''' is prokaryotic and recognizes base-base mismatches and small insertion/deletion mispairs<ref>PMID:11048711</ref> .<br /> |
| - | '''MutL''' enhances recognition of mismatches <br /> | + | '''MutL''' enhances recognition of mismatches<ref>PMID:15470502</ref> <br /> |
| - | '''MutH''' is the eukaryotic homolog of MutS<br /> | + | '''MutH''' is the eukaryotic homolog of MutS <br /> |
| - | '''MLH1, MLH3, PMS1, PMS2''' are the human homologs of MutL<br /> | + | '''MLH1, MLH3, PMS1, PMS2''' are the human homologs of MutL<ref>PMID:15475387</ref> <br /> |
== Disease == | == Disease == | ||
Revision as of 09:29, 30 June 2022
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References
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Lamers MH, Perrakis A, Enzlin JH, Winterwerp HH, de Wind N, Sixma TK. The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature. 2000 Oct 12;407(6805):711-7. PMID:11048711 doi:10.1038/35037523
- ↑ Guarne A, Ramon-Maiques S, Wolff EM, Ghirlando R, Hu X, Miller JH, Yang W. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J. 2004 Oct 27;23(21):4134-45. Epub 2004 Oct 7. PMID:15470502
- ↑ Ellison AR, Lofing J, Bitter GA. Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain. Nucleic Acids Res. 2004 Oct 8;32(18):5321-38. doi: 10.1093/nar/gkh855. Print, 2004. PMID:15475387 doi:http://dx.doi.org/10.1093/nar/gkh855
