8dai
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==E. coli DHFR complex with NADP+ and 10-methylfolate== | |
| - | + | <StructureSection load='8dai' size='340' side='right'caption='[[8dai]], [[Resolution|resolution]] 1.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8dai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DAI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=R6F:10-methylfolic+acid'>R6F</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dai OCA], [https://pdbe.org/8dai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dai RCSB], [https://www.ebi.ac.uk/pdbsum/8dai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dai ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brookner DE]] | ||
| + | [[Category: Greisman JB]] | ||
| + | [[Category: Hekstra DR]] | ||
Revision as of 09:37, 21 June 2023
E. coli DHFR complex with NADP+ and 10-methylfolate
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