7f8i
From Proteopedia
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==Crystal structure of HPV6 L1 pentamer== | ==Crystal structure of HPV6 L1 pentamer== | ||
| - | <StructureSection load='7f8i' size='340' side='right'caption='[[7f8i]]' scene=''> | + | <StructureSection load='7f8i' size='340' side='right'caption='[[7f8i]], [[Resolution|resolution]] 3.37Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F8I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7f8i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_6 Human papillomavirus type 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F8I FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f8i OCA], [https://pdbe.org/7f8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f8i RCSB], [https://www.ebi.ac.uk/pdbsum/7f8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f8i ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f8i OCA], [https://pdbe.org/7f8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f8i RCSB], [https://www.ebi.ac.uk/pdbsum/7f8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f8i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/Q9W9C6_9PAPI Q9W9C6_9PAPI]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002][RuleBase:RU361248] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human papillomavirus type 6]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gu Y]] | [[Category: Gu Y]] | ||
Revision as of 06:36, 8 September 2022
Crystal structure of HPV6 L1 pentamer
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