7lh8
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131== | ==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131== | ||
| - | <StructureSection load='7lh8' size='340' side='right'caption='[[7lh8]]' scene=''> | + | <StructureSection load='7lh8' size='340' side='right'caption='[[7lh8]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XZG:(5R)-1-ethyl-5-(4-methylphenyl)-7-({1-[(4-nitrophenyl)methyl]piperidin-4-yl}methyl)-5,7,8,9-tetrahydro-1H-pyrrolo[3,4 5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione'>XZG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chan A]] | [[Category: Chan A]] | ||
[[Category: Schonbrunn E]] | [[Category: Schonbrunn E]] | ||
Revision as of 06:38, 8 September 2022
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131
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