7xkm
From Proteopedia
(Difference between revisions)
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==Crystal structure of DNA-Ag(I) rod comprising a one-dimensional array of 11 silver ions== | ==Crystal structure of DNA-Ag(I) rod comprising a one-dimensional array of 11 silver ions== | ||
| - | <StructureSection load='7xkm' size='340' side='right'caption='[[7xkm]]' scene=''> | + | <StructureSection load='7xkm' size='340' side='right'caption='[[7xkm]], [[Resolution|resolution]] 2.79Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XKM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7xkm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XKM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xkm OCA], [https://pdbe.org/7xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xkm RCSB], [https://www.ebi.ac.uk/pdbsum/7xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xkm ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xkm OCA], [https://pdbe.org/7xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xkm RCSB], [https://www.ebi.ac.uk/pdbsum/7xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xkm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DNA/RNA duplexes containing metal-ion-mediated base pairs (metallo-base pairs) have potential applications in developing nucleic acid-based nanodevices and genetic code expansion. Many metallo-base pairs are formed within duplexes stabilized by Watson-Crick base pairs. Recently, the crystal structure of an Ag(I) -DNA nanowire with an uninterrupted one-dimensional silver array was determined. Here, we present a new DNA helical wire, the "Ag(I) -DNA rod", containing an uninterrupted array of 11 Ag(I) ions. The Ag(I) -DNA rod consisted of only C-Ag(I) -C, G-Ag(I) -G, G-Ag(I) -5-bromouracil ((Br) U), and (Br) U-Ag(I) -(Br) U metallo base pairs, with no Watson-Crick pairs. The Ag(I) -DNA rods were connected by non-canonical G-G pairs in crystals. Notably, data from our absorbance, circular dichroism, nuclear magnetic resonance, and mass spectrometry analyses suggested that the Ag(I) -DNA rods formed in solution, as well as within crystals. | ||
| + | |||
| + | A Novel Ag(I) -DNA Rod Comprising a One-Dimensional Array of 11 Silver Ions within a Double Helical Structure.,Atsugi T, Ono A, Tasaka M, Eguchi N, Fujiwara S, Kondo J Angew Chem Int Ed Engl. 2022 May 31:e202204798. doi: 10.1002/anie.202204798. PMID:35641885<ref>PMID:35641885</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7xkm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Atsugi T]] | + | [[Category: Atsugi, T]] |
| - | [[Category: Kondo J]] | + | [[Category: Kondo, J]] |
| - | [[Category: Ono A]] | + | [[Category: Ono, A]] |
| + | [[Category: Dna]] | ||
| + | [[Category: Rod]] | ||
| + | [[Category: Silver]] | ||
Revision as of 05:14, 10 August 2022
Crystal structure of DNA-Ag(I) rod comprising a one-dimensional array of 11 silver ions
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Categories: Large Structures | Atsugi, T | Kondo, J | Ono, A | Dna | Rod | Silver
