7fgy
From Proteopedia
(Difference between revisions)
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<StructureSection load='7fgy' size='340' side='right'caption='[[7fgy]], [[Resolution|resolution]] 2.67Å' scene=''> | <StructureSection load='7fgy' size='340' side='right'caption='[[7fgy]], [[Resolution|resolution]] 2.67Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7fgy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FGY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7fgy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FGY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4TS:5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]pyrimidine-2,4-diamine'>4TS</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4TS:5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]pyrimidine-2,4-diamine'>4TS</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fgy OCA], [https://pdbe.org/7fgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fgy RCSB], [https://www.ebi.ac.uk/pdbsum/7fgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fgy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fgy OCA], [https://pdbe.org/7fgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fgy RCSB], [https://www.ebi.ac.uk/pdbsum/7fgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fgy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). | + | [[https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kamchonwongpaisan, S]] | ||
| - | [[Category: Saeyang, T]] | ||
| - | [[Category: Tarnchompoo, B]] | ||
| - | [[Category: Taweechai, S]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Yoomuang, A]] | ||
| - | [[Category: Yuthavong, Y]] | ||
| - | [[Category: Yuvaniyama, J]] | ||
| - | [[Category: Antifolate]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Oxidoreductase]] | ||
| - | [[Category: Thymidylate synthase]] | ||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
| + | [[Category: Kamchonwongpaisan S]] | ||
| + | [[Category: Saeyang T]] | ||
| + | [[Category: Tarnchompoo B]] | ||
| + | [[Category: Taweechai S]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Yoomuang A]] | ||
| + | [[Category: Yuthavong Y]] | ||
| + | [[Category: Yuvaniyama J]] | ||
Revision as of 04:39, 8 September 2022
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP
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