3tfm

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Current revision (17:31, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3tfm' size='340' side='right'caption='[[3tfm]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
<StructureSection load='3tfm' size='340' side='right'caption='[[3tfm]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Myo10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfm OCA], [https://pdbe.org/3tfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfm RCSB], [https://www.ebi.ac.uk/pdbsum/3tfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfm OCA], [https://pdbe.org/3tfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfm RCSB], [https://www.ebi.ac.uk/pdbsum/3tfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfm ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYO10_RAT MYO10_RAT] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts (By similarity).[UniProtKB:Q9HD67]<ref>PMID:21965296</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lu, Q]]
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[[Category: Rattus norvegicus]]
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[[Category: Wei, Z]]
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[[Category: Lu Q]]
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[[Category: Yan, J]]
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[[Category: Wei Z]]
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[[Category: Yu, J]]
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[[Category: Yan J]]
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[[Category: Zhang, M]]
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[[Category: Yu J]]
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[[Category: Motor protein]]
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[[Category: Zhang M]]
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[[Category: Split ph domain]]
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Current revision

Myosin X PH1N-PH2-PH1C tandem

PDB ID 3tfm

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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