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1hn1

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{{STRUCTURE_1hn1| PDB=1hn1 | SCENE= }}
{{STRUCTURE_1hn1| PDB=1hn1 | SCENE= }}
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'''E. COLI (LAC Z) BETA-GALACTOSIDASE (ORTHORHOMBIC)'''
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===E. COLI (LAC Z) BETA-GALACTOSIDASE (ORTHORHOMBIC)===
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==Overview==
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Flash-freezing, which has become routine in macromolecular X-ray crystallography, causes the crystal to contract substantially. In the case of Escherichia coli beta-galactosidase the changes are reversible and are shown to be due to lattice repacking. On cooling, the area of the protein surface involved in lattice contacts increases by 50 %. There are substantial alterations in intermolecular contacts, these changes being dominated by the long, polar side-chains. For entropic reasons such side-chains, as well as surface solvent molecules, tend to be somewhat disordered at room temperature but can form extensive hydrogen-bonded networks on cooling. Low-temperature density measurements suggest that, at least in some cases, the beneficial effect of cryosolvents may be due to a density increase on vitrification which reduces the volume of bulk solvent that needs to be expelled from the crystal. Analysis of beta-galactosidase and several other proteins suggests that both intramolecular and intermolecular contact interfaces can be perturbed by cryocooling but that the changes tend to be more dramatic in the latter case. The temperature-dependence of the intermolecular interactions suggests that caution may be necessary in interpreting protein-protein and protein-nucleic acid interactions based on low-temperature crystal structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_11518535}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11518535 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11518535}}
==About this Structure==
==About this Structure==
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[[Category: Fibronectin]]
[[Category: Fibronectin]]
[[Category: Jelly roll barrel]]
[[Category: Jelly roll barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:01:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:25:12 2008''

Revision as of 05:25, 1 July 2008

Image:1hn1.png

Template:STRUCTURE 1hn1

E. COLI (LAC Z) BETA-GALACTOSIDASE (ORTHORHOMBIC)

Template:ABSTRACT PUBMED 11518535

About this Structure

1HN1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Reversible lattice repacking illustrates the temperature dependence of macromolecular interactions., Juers DH, Matthews BW, J Mol Biol. 2001 Aug 24;311(4):851-62. PMID:11518535

Page seeded by OCA on Tue Jul 1 08:25:12 2008

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