This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1hn9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1hn9.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1hn9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hn9| PDB=1hn9 | SCENE= }}
{{STRUCTURE_1hn9| PDB=1hn9 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III'''
+
===CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III===
-
==Overview==
+
<!--
-
Beta-ketoacyl-acyl carrier protein synthase III (FabH), the most divergent member of the family of condensing enzymes, is a key catalyst in bacterial fatty acid biosynthesis and a promising target for novel antibiotics. We report here the crystal structures of FabH determined in the presence and absence of acetyl-CoA. These structures display a fold that is common for condensing enzymes. The observed acetylation of Cys(112) proves its catalytic role and clearly defines the primer binding pocket. Modeling based on a bound CoA molecule suggests catalytic roles for His(244) and Asn(274). The structures provide the molecular basis for FabH substrate specificity and reaction mechanism and are important for structure-based design of novel antibiotics.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10593943}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10593943 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10593943}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Smith, W W.]]
[[Category: Smith, W W.]]
[[Category: Fabh]]
[[Category: Fabh]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:02:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:25:35 2008''

Revision as of 05:25, 1 July 2008

Image:1hn9.png

Template:STRUCTURE 1hn9

CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III

Template:ABSTRACT PUBMED 10593943

About this Structure

1HN9 is a Single protein structure of sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1d9b. Full crystallographic information is available from OCA.

Reference

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis., Qiu X, Janson CA, Konstantinidis AK, Nwagwu S, Silverman C, Smith WW, Khandekar S, Lonsdale J, Abdel-Meguid SS, J Biol Chem. 1999 Dec 17;274(51):36465-71. PMID:10593943

Page seeded by OCA on Tue Jul 1 08:25:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hn9"
Personal tools