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1hnd

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{{STRUCTURE_1hnd| PDB=1hnd | SCENE= }}
{{STRUCTURE_1hnd| PDB=1hnd | SCENE= }}
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'''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III-COA COMPLEX'''
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===CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III-COA COMPLEX===
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==Overview==
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beta-Ketoacyl-acyl carrier protein synthase III (FabH) is a condensing enzyme that plays central roles in fatty acid biosynthesis. Three-dimensional structures of E. coli FabH in the presence and absence of ligands have been refined to 1.46 A resolution. The structures of improved accuracy revealed detailed interactions involved in ligand binding. These structures also provided new insights into the FabH mechanism, e.g. the possible role of a water or hydroxyl anion in Cys112 deprotonation. A structure of the apo enzyme uncovered large conformational changes in the active site, exemplified by the disordering of four essential loops (84-86, 146-152, 185-217 and 305-307) and the movement of catalytic residues (Cys112 and His244). The disordering of the loops leads to greater than 50 % reduction in the FabH dimer interface, suggesting a dynamic nature for an unusually large portion of the dimer interface. The existence of a large solvent-accessible channel in the dimer interface as well as two cis-peptides (cis-Pro88 and cis-Phe308) in two of the disordered loops may explain the observed structural instabilities.
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The line below this paragraph, {{ABSTRACT_PUBMED_11243824}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11243824 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11243824}}
==About this Structure==
==About this Structure==
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[[Category: Smith, W W.]]
[[Category: Smith, W W.]]
[[Category: Fabh]]
[[Category: Fabh]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:02:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:25:47 2008''

Revision as of 05:25, 1 July 2008

Image:1hnd.png

Template:STRUCTURE 1hnd

CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III-COA COMPLEX

Template:ABSTRACT PUBMED 11243824

About this Structure

1HND is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Refined structures of beta-ketoacyl-acyl carrier protein synthase III., Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK, J Mol Biol. 2001 Mar 16;307(1):341-56. PMID:11243824

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