8a59
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==C-type lectin-like domain (CTLD) and Sushi-like domain of human CD93== | |
| + | <StructureSection load='8a59' size='340' side='right'caption='[[8a59]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A59 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a59 OCA], [https://pdbe.org/8a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a59 RCSB], [https://www.ebi.ac.uk/pdbsum/8a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a59 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C1QR1_HUMAN C1QR1_HUMAN] Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Blocking the signaling activated by the plasma membrane receptor CD93 has recently been demonstrated a useful tool in antiangiogenic treatment and oncotherapy. In the proliferating endothelium, CD93 regulates cell adhesion, migration, and vascular maturation, yet it is unclear how CD93 interacts with the extracellular matrix activating signaling pathways involved in the vascular remodeling. Here for the first time we show that in endothelial cells CD93 is structured as a dimer and that this oligomeric form is physiologically instrumental for the binding of CD93 to its ligand Multimerin-2. Crystallographic X-ray analysis of recombinant CD93 reveals the crucial role played by the C-type lectin-like and sushi-like domains in arranging as an antiparallel dimer to achieve a functional binding state, providing key information for the future design of new drugs able to hamper CD93 function in neovascular pathologies. | ||
| - | + | Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells.,Barbera S, Raucci L, Tassone G, Tinti L, Prischi F, Santucci A, Mongiat M, Tosi GM, Galvagni F, Dimberg A, Pozzi C, Orlandini M Int J Biol Macromol. 2022 Oct 18. pii: S0141-8130(22)02378-9. doi:, 10.1016/j.ijbiomac.2022.10.136. PMID:36265539<ref>PMID:36265539</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8a59" style="background-color:#fffaf0;"></div> |
| - | [[Category: Barbera | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Barbera S]] | ||
| + | [[Category: Orlandini M]] | ||
| + | [[Category: Pozzi C]] | ||
| + | [[Category: Raucci L]] | ||
| + | [[Category: Tassone G]] | ||
Revision as of 07:23, 3 November 2022
C-type lectin-like domain (CTLD) and Sushi-like domain of human CD93
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