1hnh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1hnh.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1hnh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hnh| PDB=1hnh | SCENE= }}
{{STRUCTURE_1hnh| PDB=1hnh | SCENE= }}
-
'''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + DEGRADED FORM OF ACETYL-COA'''
+
===CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + DEGRADED FORM OF ACETYL-COA===
-
==Overview==
+
<!--
-
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is a condensing enzyme that plays central roles in fatty acid biosynthesis. Three-dimensional structures of E. coli FabH in the presence and absence of ligands have been refined to 1.46 A resolution. The structures of improved accuracy revealed detailed interactions involved in ligand binding. These structures also provided new insights into the FabH mechanism, e.g. the possible role of a water or hydroxyl anion in Cys112 deprotonation. A structure of the apo enzyme uncovered large conformational changes in the active site, exemplified by the disordering of four essential loops (84-86, 146-152, 185-217 and 305-307) and the movement of catalytic residues (Cys112 and His244). The disordering of the loops leads to greater than 50 % reduction in the FabH dimer interface, suggesting a dynamic nature for an unusually large portion of the dimer interface. The existence of a large solvent-accessible channel in the dimer interface as well as two cis-peptides (cis-Pro88 and cis-Phe308) in two of the disordered loops may explain the observed structural instabilities.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11243824}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11243824 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11243824}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Smith, W W.]]
[[Category: Smith, W W.]]
[[Category: Fabh]]
[[Category: Fabh]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:02:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:26:07 2008''

Revision as of 05:26, 1 July 2008

Image:1hnh.png

Template:STRUCTURE 1hnh

CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + DEGRADED FORM OF ACETYL-COA

Template:ABSTRACT PUBMED 11243824

About this Structure

1HNH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Refined structures of beta-ketoacyl-acyl carrier protein synthase III., Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK, J Mol Biol. 2001 Mar 16;307(1):341-56. PMID:11243824

Page seeded by OCA on Tue Jul 1 08:26:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hnh"
Personal tools