8d5q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==TCR TG6 in complex with Ld-HF10== | |
| + | <StructureSection load='8d5q' size='340' side='right'caption='[[8d5q]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8d5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D5Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d5q OCA], [https://pdbe.org/8d5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d5q RCSB], [https://www.ebi.ac.uk/pdbsum/8d5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d5q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vbeta2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vbeta2-containing TCRs and correlates with an unusual Valpha-Vbeta interface, CDR loop conformations, and Vbeta2-specific germline contacts with peptides. Vbeta2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses. | ||
| - | + | Peptide Centric Vbeta Specific Germline Contacts Shape a Specialist T Cell Response.,Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S Front Immunol. 2022 Jul 29;13:847092. doi: 10.3389/fimmu.2022.847092. eCollection, 2022. PMID:35967379<ref>PMID:35967379</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8d5q" style="background-color:#fffaf0;"></div> |
| - | [[Category: Dai | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Toxoplasma gondii]] | ||
| + | [[Category: Dai S]] | ||
| + | [[Category: Wang Y]] | ||
Revision as of 06:59, 14 September 2022
TCR TG6 in complex with Ld-HF10
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