1ho2

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{{STRUCTURE_1ho2| PDB=1ho2 | SCENE= }}
{{STRUCTURE_1ho2| PDB=1ho2 | SCENE= }}
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'''NMR STRUCTURE OF THE POTASSIUM CHANNEL FRAGMENT L45 IN MICELLES'''
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===NMR STRUCTURE OF THE POTASSIUM CHANNEL FRAGMENT L45 IN MICELLES===
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==Overview==
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The propagation of action potentials during neuronal signal transduction in phospholipid membranes is mediated by ion channels, a diverse group of membrane proteins. The S4-S5 linker peptide (S4-S5), that connects the S4 and S5 transmembrane segments of voltage-gated potassium channels is an important region of the Shaker ion-channel protein. Despite its importance, very little is known about its structure. Here we provide evidence for an amphipathic alpha-helical conformation of a synthetic S4-S5 peptide of the voltage-gated Drosophila melanogaster Shaker potassium channel in water/trifluoroethanol and in aqueous phospholipid micelles. The three-dimensional solution structures of the S4-S5 peptide were obtained by high-resolution nuclear magnetic resonance spectroscopy and distance-geometry/simulated-annealing calculations. The detailed structural features are discussed with respect to model studies and available mutagenesis data on the mechanism and selectivity of the potassium channel.
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{{ABSTRACT_PUBMED_12023222}}
==About this Structure==
==About this Structure==
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1HO2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO2 OCA].
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1HO2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HO2 OCA].
==Reference==
==Reference==
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[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
[[Category: Amphipathic]]
[[Category: Amphipathic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:27:28 2008''

Revision as of 05:27, 1 July 2008

Image:1ho2.png

Template:STRUCTURE 1ho2

NMR STRUCTURE OF THE POTASSIUM CHANNEL FRAGMENT L45 IN MICELLES

Template:ABSTRACT PUBMED 12023222

About this Structure

1HO2 is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the S4-S5 segment of the Shaker potassium channel., Ohlenschlager O, Hojo H, Ramachandran R, Gorlach M, Haris PI, Biophys J. 2002 Jun;82(6):2995-3002. PMID:12023222

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