1fns
From Proteopedia
(New page: 200px<br /> <applet load="1fns" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fns, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1fns.gif|left|200px]]<br /> | + | [[Image:1fns.gif|left|200px]]<br /><applet load="1fns" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1fns, resolution 2.00Å" /> | caption="1fns, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4'''<br /> | '''CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4'''<br /> | ||
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==Overview== | ==Overview== | ||
Platelet participation in hemostasis and arterial thrombosis requires the, binding of glycoprotein (GP) Ibalpha to von Willebrand factor (vWF)., Hemodynamic forces enhance this interaction, an effect mimicked by the, substitution I546V in the vWF A1 domain. A water molecule becomes, internalized near the deleted Ile methyl group. The change in, hydrophobicity of the local environment causes positional changes, propagated over a distance of 27 A. As a consequence, a major, reorientation of a peptide plane occurs in a surface loop involved in GP, Ibalpha binding. This distinct vWF conformation shows increased platelet, adhesion and provides a structural model for the initial regulation of, thrombus formation. | Platelet participation in hemostasis and arterial thrombosis requires the, binding of glycoprotein (GP) Ibalpha to von Willebrand factor (vWF)., Hemodynamic forces enhance this interaction, an effect mimicked by the, substitution I546V in the vWF A1 domain. A water molecule becomes, internalized near the deleted Ile methyl group. The change in, hydrophobicity of the local environment causes positional changes, propagated over a distance of 27 A. As a consequence, a major, reorientation of a peptide plane occurs in a surface loop involved in GP, Ibalpha binding. This distinct vWF conformation shows increased platelet, adhesion and provides a structural model for the initial regulation of, thrombus formation. | ||
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| - | ==Disease== | ||
| - | Known diseases associated with this structure: von Willebrand disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193400 193400]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 1FNS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1FNS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: von willebrand factor]] | [[Category: von willebrand factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:08:40 2008'' |
Revision as of 13:08, 23 January 2008
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CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4
Overview
Platelet participation in hemostasis and arterial thrombosis requires the, binding of glycoprotein (GP) Ibalpha to von Willebrand factor (vWF)., Hemodynamic forces enhance this interaction, an effect mimicked by the, substitution I546V in the vWF A1 domain. A water molecule becomes, internalized near the deleted Ile methyl group. The change in, hydrophobicity of the local environment causes positional changes, propagated over a distance of 27 A. As a consequence, a major, reorientation of a peptide plane occurs in a surface loop involved in GP, Ibalpha binding. This distinct vWF conformation shows increased platelet, adhesion and provides a structural model for the initial regulation of, thrombus formation.
About this Structure
1FNS is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule., Celikel R, Ruggeri ZM, Varughese KI, Nat Struct Biol. 2000 Oct;7(10):881-4. PMID:11017197
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