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7uan
From Proteopedia
(Difference between revisions)
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==Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with (6-(3-(4,4-difluoropiperidin-1-yl)propyl)-4-methylpyridin-2-amine)== | ==Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with (6-(3-(4,4-difluoropiperidin-1-yl)propyl)-4-methylpyridin-2-amine)== | ||
| - | <StructureSection load='7uan' size='340' side='right'caption='[[7uan]]' scene=''> | + | <StructureSection load='7uan' size='340' side='right'caption='[[7uan]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UAN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7uan]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UAN FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uan OCA], [https://pdbe.org/7uan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uan RCSB], [https://www.ebi.ac.uk/pdbsum/7uan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uan ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=M5L:6-[3-(4,4-difluoropiperidin-1-yl)propyl]-4-methylpyridin-2-amine'>M5L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uan OCA], [https://pdbe.org/7uan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uan RCSB], [https://www.ebi.ac.uk/pdbsum/7uan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uan ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
[[Category: Li H]] | [[Category: Li H]] | ||
[[Category: Poulos TL]] | [[Category: Poulos TL]] | ||
Revision as of 05:51, 8 September 2022
Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with (6-(3-(4,4-difluoropiperidin-1-yl)propyl)-4-methylpyridin-2-amine)
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