7uy5

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====
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==Tetrahymena telomerase with CST==
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<StructureSection load='7uy5' size='340' side='right'caption='[[7uy5]]' scene=''>
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<StructureSection load='7uy5' size='340' side='right'caption='[[7uy5]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7uy5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UY5 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uy5 OCA], [https://pdbe.org/7uy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uy5 RCSB], [https://www.ebi.ac.uk/pdbsum/7uy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uy5 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uy5 OCA], [https://pdbe.org/7uy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uy5 RCSB], [https://www.ebi.ac.uk/pdbsum/7uy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uy5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/LARP7_TETTS LARP7_TETTS]] RNA-binding protein required for assembly of the holoenzyme telomerase ribonucleoprotein (RNP) complex (PubMed:15131081, PubMed:15696174, PubMed:16507983, PubMed:17322903, PubMed:20713447, PubMed:22315458, PubMed:22705372). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:15696174, PubMed:17322903, PubMed:20713447). TAP65/p65 specifically binds telomerase RNA template TER and is required for biogenesis and placement of the TER stem-terminus element: TAP65/p65 first protects the 3'-end of TER from degradation and acts as a chaperone to correctly fold TER for protein binding; it then bends TER stem-loop IV to position it for interaction of stem-loop IV with catalytic TERT RNA-binding domain (PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:22315458, PubMed:22705372).<ref>PMID:15131081</ref> <ref>PMID:15696174</ref> <ref>PMID:16507983</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref> <ref>PMID:22315458</ref> <ref>PMID:22705372</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Tetrahymena thermophila]]
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[[Category: Chan H]]
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[[Category: Feigon J]]
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[[Category: He Y]]
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[[Category: Liu B]]
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[[Category: Song H]]
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[[Category: Susac L]]
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[[Category: Wang Y]]
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[[Category: Zhou ZH]]

Revision as of 16:49, 7 September 2022

Tetrahymena telomerase with CST

PDB ID 7uy5

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