7wj5
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity== |
| - | <StructureSection load='7wj5' size='340' side='right'caption='[[7wj5]]' scene=''> | + | <StructureSection load='7wj5' size='340' side='right'caption='[[7wj5]], [[Resolution|resolution]] 3.72Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wj5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WJ5 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wj5 OCA], [https://pdbe.org/7wj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wj5 RCSB], [https://www.ebi.ac.uk/pdbsum/7wj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wj5 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRD_001216:Somatostatin-14'>PRD_001216</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wj5 OCA], [https://pdbe.org/7wj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wj5 RCSB], [https://www.ebi.ac.uk/pdbsum/7wj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wj5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Heo YS]] |
| + | [[Category: Ishimoto N]] | ||
| + | [[Category: Jeon YE]] | ||
| + | [[Category: Lee WT]] | ||
| + | [[Category: Park SY]] | ||
| + | [[Category: Song J]] | ||
| + | [[Category: Woo H]] | ||
| + | [[Category: Yoon EJ]] | ||
| + | [[Category: Yun J-H]] | ||
Revision as of 05:53, 8 September 2022
Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity
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Categories: Escherichia coli | Homo sapiens | Large Structures | Heo YS | Ishimoto N | Jeon YE | Lee WT | Park SY | Song J | Woo H | Yoon EJ | Yun J-H
