8a46
From Proteopedia
(Difference between revisions)
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==Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879== | ==Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879== | ||
| - | <StructureSection load='8a46' size='340' side='right'caption='[[8a46]]' scene=''> | + | <StructureSection load='8a46' size='340' side='right'caption='[[8a46]], [[Resolution|resolution]] 1.32Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A46 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8a46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A46 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a46 OCA], [https://pdbe.org/8a46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a46 RCSB], [https://www.ebi.ac.uk/pdbsum/8a46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a46 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L5F:2-[(1S,2R,8S)-2,4,32-trimethyl-28,28-bis(oxidanylidene)-19,22,27-trioxa-28$l^{6}-thia-1,14,15,16-tetrazahexacyclo[21.5.3.1^{3,7}.1^{9,13}.0^{12,16}.0^{26,30}]tritriaconta-3(33),4,6,9(32),10,12,14,23,25,30-decaen-8-yl]ethanoic+acid'>L5F</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a46 OCA], [https://pdbe.org/8a46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a46 RCSB], [https://www.ebi.ac.uk/pdbsum/8a46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a46 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Delerive P]] | [[Category: Delerive P]] | ||
[[Category: Miallau L]] | [[Category: Miallau L]] | ||
[[Category: Vuillard L]] | [[Category: Vuillard L]] | ||
[[Category: Weber C]] | [[Category: Weber C]] | ||
Revision as of 05:58, 8 September 2022
Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879
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