1hoc

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[[Image:1hoc.gif|left|200px]]
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{{Seed}}
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[[Image:1hoc.png|left|200px]]
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{{STRUCTURE_1hoc| PDB=1hoc | SCENE= }}
{{STRUCTURE_1hoc| PDB=1hoc | SCENE= }}
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'''THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION'''
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===THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION===
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==Overview==
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Solution at 2.4 A resolution of the structure of H-2Db with the influenza virus peptide NP366-374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype, revealing a strategy that maximizes the repertoire of peptides than can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, exposing the arch residues to TCR contact and requiring the peptide to be at least 9 residues. This ridge occurs in about 40% of the known murine D and L allelic molecules, classifying them as a structural subgroup.
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The line below this paragraph, {{ABSTRACT_PUBMED_7506996}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7506996 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7506996}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, W.]]
[[Category: Zhang, W.]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:03:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:28:03 2008''

Revision as of 05:28, 1 July 2008

Image:1hoc.png

Template:STRUCTURE 1hoc

THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION

Template:ABSTRACT PUBMED 7506996

About this Structure

1HOC is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection., Young AC, Zhang W, Sacchettini JC, Nathenson SG, Cell. 1994 Jan 14;76(1):39-50. PMID:7506996

Page seeded by OCA on Tue Jul 1 08:28:03 2008

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