3ju9

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Current revision (08:03, 6 September 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ju9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_brasiliensis Canavalia brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JU9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ju9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_brasiliensis Canavalia brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JU9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1azd|1azd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ju9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ju9 OCA], [https://pdbe.org/3ju9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ju9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ju9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ju9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ju9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ju9 OCA], [https://pdbe.org/3ju9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ju9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ju9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ju9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
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[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Canavalia brasiliensis]]
[[Category: Canavalia brasiliensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Benevides, R G]]
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[[Category: Benevides RG]]
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[[Category: Bezerra, E H.S]]
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[[Category: Bezerra EHS]]
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[[Category: Bezerra, G A]]
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[[Category: Bezerra GA]]
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[[Category: Bezerra, M J.B]]
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[[Category: Bezerra MJB]]
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[[Category: Cavada, B S]]
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[[Category: Cavada BS]]
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[[Category: Delatorre, P]]
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[[Category: Delatorre P]]
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[[Category: Marinho, E S]]
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[[Category: Marinho ES]]
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[[Category: Moura, T R]]
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[[Category: Moura TR]]
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[[Category: Nagano, C S]]
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[[Category: Nagano CS]]
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[[Category: Rocha, B A.M]]
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[[Category: Rocha BAM]]
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[[Category: Agglutinin]]
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[[Category: Conbr]]
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[[Category: Lectin]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of a lectin from Canavalia brasiliensis seed (ConBr) complexed with alpha-aminobutyric acid

PDB ID 3ju9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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