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3u80

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Current revision (13:50, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3u80' size='340' side='right'caption='[[3u80]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3u80' size='340' side='right'caption='[[3u80]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Biflj Biflj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U80 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum_subsp._longum_JDM301 Bifidobacterium longum subsp. longum JDM301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U80 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BLJ_0876 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759350 BIFLJ])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u80 OCA], [https://pdbe.org/3u80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u80 RCSB], [https://www.ebi.ac.uk/pdbsum/3u80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u80 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u80 OCA], [https://pdbe.org/3u80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u80 RCSB], [https://www.ebi.ac.uk/pdbsum/3u80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u80 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/D6ZTY6_BIFLJ D6ZTY6_BIFLJ]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[https://www.uniprot.org/uniprot/D6ZTY6_BIFLJ D6ZTY6_BIFLJ] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dehydroquinate dehydratase (DHQD) catalyzes the third step in the biosynthetic shikimate pathway. Here we identify a Bifidobacterium longum protein with high sequence homology to type II DHQDs but no detectable DHQD activity under standard assay conditions. A crystal structure reveals that the B. longum protein adopts a DHQD-like tertiary structure but a distinct quaternary state. Apparently forming a dimer, the B. longum protein lacks the active site aspartic acid contributed from a neighboring protomer in the type II DHQD dodecamer. Relating to the absence of protein-protein interactions established in the type II DHQD dodecameric assembly, substantial conformational changes distinguish the would-be active site of the B. longum protein. As B. longum possess no other genes with homology to known DHQDs, these findings imply a unique DHQD activity within B. longum.
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Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum.,Light SH, Krishna SN, Bergan RC, Lavie A, Anderson WF J Struct Funct Genomics. 2013 Mar;14(1):25-30. doi: 10.1007/s10969-013-9149-7., Epub 2013 Mar 29. PMID:23539270<ref>PMID:23539270</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3u80" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Biflj]]
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[[Category: Bifidobacterium longum subsp. longum JDM301]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Lavie A]]
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[[Category: Lavie, A]]
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[[Category: Light SH]]
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[[Category: Light, S H]]
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[[Category: Minasov G]]
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[[Category: Minasov, G]]
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[[Category: Papazisi L]]
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[[Category: Papazisi, L]]
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[[Category: Shuvalova L]]
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[[Category: Shuvalova, L]]
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[[Category: Csgid]]
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[[Category: Unknown function]]
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Current revision

1.60 Angstrom Resolution Crystal Structure of a 3-Dehydroquinate Dehydratase-like Protein from Bifidobacterium longum

PDB ID 3u80

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