This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3u83

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:35, 1 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3u83' size='340' side='right'caption='[[3u83]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3u83' size='340' side='right'caption='[[3u83]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3u83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U83 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3u83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U83 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.499&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3alp|3alp]], [[3u82|3u82]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u83 OCA], [https://pdbe.org/3u83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u83 RCSB], [https://www.ebi.ac.uk/pdbsum/3u83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u83 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u83 OCA], [https://pdbe.org/3u83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u83 RCSB], [https://www.ebi.ac.uk/pdbsum/3u83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u83 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/NECT1_HUMAN NECT1_HUMAN] Isolated cleft lip;Cleft lip/palate-ectodermal dysplasia syndrome;Cleft lip and alveolus;Cleft lip/palate. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
+
[https://www.uniprot.org/uniprot/NECT1_HUMAN NECT1_HUMAN] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.<ref>PMID:21980294</ref> (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.<ref>PMID:7721102</ref> <ref>PMID:9657005</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 29: Line 28:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Fan, Z]]
+
[[Category: Fan Z]]
-
[[Category: Gao, G F]]
+
[[Category: Gao GF]]
-
[[Category: Guo, Z]]
+
[[Category: Guo Z]]
-
[[Category: Lu, G]]
+
[[Category: Lu G]]
-
[[Category: Qi, J]]
+
[[Category: Qi J]]
-
[[Category: Shi, Y]]
+
[[Category: Shi Y]]
-
[[Category: Wang, J]]
+
[[Category: Wang J]]
-
[[Category: Yan, J]]
+
[[Category: Yan J]]
-
[[Category: Zhang, N]]
+
[[Category: Zhang N]]
-
[[Category: Cell adhesion]]
+
-
[[Category: Hinge region plasiticity]]
+
-
[[Category: Nectin-1]]
+

Current revision

Crystal structure of nectin-1

PDB ID 3u83

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3u83"
Personal tools