3uc0

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<StructureSection load='3uc0' size='340' side='right'caption='[[3uc0]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='3uc0' size='340' side='right'caption='[[3uc0]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uc0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chimpansee_troglodytes Chimpansee troglodytes] and [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UC0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uc0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4] and [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UC0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uaj|3uaj]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">envelope ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11070 Dengue virus 4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc0 OCA], [https://pdbe.org/3uc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uc0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc0 OCA], [https://pdbe.org/3uc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uc0 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q91AI1_9FLAV Q91AI1_9FLAV]
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The four serotypes of dengue virus (DENV-1 to -4) cause the most important emerging viral disease. Protein E, the principal viral envelope glycoprotein, mediates fusion of the viral and endosomal membranes during virus entry and is the target of neutralizing antibodies. However, the epitopes of strongly neutralizing human antibodies have not been described despite their importance to vaccine development. The chimpanzee Mab 5H2 potently neutralizes DENV-4 by binding to domain I of E. The crystal structure of Fab 5H2 bound to E from DENV-4 shows that antibody binding prevents formation of the fusogenic hairpin conformation of E, which together with in-vitro assays, demonstrates that 5H2 neutralizes by blocking membrane fusion in the endosome. Furthermore, we show that human sera from patients recovering from DENV-4 infection contain antibodies that bind to the 5H2 epitope region on domain I. This study, thus, provides new information and tools for effective vaccine design to prevent dengue disease.
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Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus.,Cockburn JJ, Navarro Sanchez ME, Goncalvez AP, Zaitseva E, Stura EA, Kikuti CM, Duquerroy S, Dussart P, Chernomordik LV, Lai CJ, Rey FA EMBO J. 2011 Dec 2. doi: 10.1038/emboj.2011.439. PMID:22139356<ref>PMID:22139356</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3uc0" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chimpansee troglodytes]]
 
[[Category: Dengue virus 4]]
[[Category: Dengue virus 4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cockburn, J J.B]]
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[[Category: Pan troglodytes]]
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[[Category: Navarro-Sanchez, M E]]
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[[Category: Cockburn JJB]]
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[[Category: Rey, F A]]
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[[Category: Navarro-Sanchez ME]]
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[[Category: Stura, E A]]
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[[Category: Rey FA]]
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[[Category: Dengue antibody membrane fusion]]
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[[Category: Stura EA]]
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[[Category: Viral protein-immune system complex]]
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Revision as of 13:54, 14 March 2024

Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2

PDB ID 3uc0

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