8dki
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cryo-EM structure of cystinosin in a lumen-open state== |
| - | + | <StructureSection load='8dki' size='340' side='right'caption='[[8dki]], [[Resolution|resolution]] 3.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8dki]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DKI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dki OCA], [https://pdbe.org/8dki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dki RCSB], [https://www.ebi.ac.uk/pdbsum/8dki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dki ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Li | + | [[https://www.uniprot.org/uniprot/CTNS_HUMAN CTNS_HUMAN]] Juvenile nephropathic cystinosis;Ocular cystinosis;Infantile nephropathic cystinosis. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CTNS_HUMAN CTNS_HUMAN]] Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:15128704). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (By similarity). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity).[UniProtKB:P57757]<ref>PMID:11689434</ref> <ref>PMID:15128704</ref> <ref>PMID:18337546</ref> <ref>PMID:22232659</ref> <ref>PMID:22649030</ref> <ref>PMID:29467429</ref> <ref>PMID:33208952</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Li X]] | ||
| + | [[Category: Schmiege P]] | ||
Revision as of 07:48, 21 September 2022
Cryo-EM structure of cystinosin in a lumen-open state
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