7xow

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====
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==Structural insights into human brain gut peptide cholecystokinin receptors==
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<StructureSection load='7xow' size='340' side='right'caption='[[7xow]]' scene=''>
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<StructureSection load='7xow' size='340' side='right'caption='[[7xow]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7xow]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xow OCA], [https://pdbe.org/7xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xow RCSB], [https://www.ebi.ac.uk/pdbsum/7xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xow ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xow OCA], [https://pdbe.org/7xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xow RCSB], [https://www.ebi.ac.uk/pdbsum/7xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xow ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/GASR_HUMAN GASR_HUMAN]] Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref> Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Mus musculus]]
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[[Category: Chen L]]
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[[Category: Ding Y]]
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[[Category: Ji S]]
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[[Category: Liao Y]]
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[[Category: Zhang H]]

Revision as of 05:03, 8 September 2022

Structural insights into human brain gut peptide cholecystokinin receptors

PDB ID 7xow

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